Drug Interaction Report

Bosentan may reduce the blood levels and effects of medroxyPROGESTERone, which may make it less reliable as a form of birth control. Alternative or additional methods of birth control should be used during treatment with bosentan to avoid unintended pregnancy. This is particularly important because bosentan may cause major birth defects in the unborn child. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.