Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Bleo 15k (bleomycin)
- brentuximab
Interactions between your drugs
bleomycin brentuximab vedotin
Applies to: Bleo 15k (bleomycin), brentuximab
CONTRAINDICATED: Coadministration of brentuximab with bleomycin may increase the risk of pulmonary toxicity. The mechanism has not been described. In a clinical trial that involved use of the two agents as part of a combination regimen, the rate of noninfectious pulmonary toxicity was higher than the historical incidence reported with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine). Patients typically reported cough and dyspnea. Interstitial infiltration and/or inflammation were observed on radiographs and computed tomographic imaging of the chest. Most patients responded to corticosteroids.
MANAGEMENT: Concomitant use of brentuximab and bleomycin is considered contraindicated.
References (1)
- (2011) "Product Information. Adcetris (brentuximab vedotin)." Seattle Genetics Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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