Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amikacin liposome
- Drotic (hydrocortisone / neomycin / polymyxin b otic)
Interactions between your drugs
neomycin topical amikacin liposome
Applies to: Drotic (hydrocortisone / neomycin / polymyxin b otic), amikacin liposome
GENERALLY AVOID: Topically applied aminoglycosides may be systemically absorbed and have potentially additive effects with systemically administered aminoglycosides. The risk of oto- and nephrotoxicity and other adverse effects of aminoglycosides may be increased.
MANAGEMENT: Topical preparations containing an aminoglycoside should not be used with other aminoglycosides in circumstances where significant systemic absorption could occur (e.g., application to burnt or broken skin; use of large quantities or on large areas for prolonged periods). The normally recommended dosages of these products should not be exceeded.
References (1)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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