Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Pepto-Bismol InstaCool (bismuth subsalicylate)
- varicella virus vaccine
Interactions between your drugs
bismuth subsalicylate varicella virus vaccine
Applies to: Pepto-Bismol InstaCool (bismuth subsalicylate), varicella virus vaccine
GENERALLY AVOID: In pediatric patients, use of varicella virus vaccine during salicylate or salicylate-containing therapy may pose a theoretical risk of Reye's syndrome based on known association of the syndrome with salicylates and natural varicella infection. Children and adolescents receiving the vaccine in U.S. clinical studies were instructed not to use salicylates for six weeks after vaccination. There were no reports of Reye's syndrome during these studies.
MANAGEMENT: Vaccine recipients less than 18 years of age should avoid the use of salicylates for six weeks after immunization with varicella virus vaccine.
References (2)
- (2001) "Product Information. Dipentum (olsalazine)." Meda Pharmaceuticals
- (2022) "Product Information. Varivax (varicella virus vaccine)." Merck & Co., Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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