Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- sarilumab
- Xeljanz Oral Solution (tofacitinib)
Interactions between your drugs
tofacitinib sarilumab
Applies to: Xeljanz Oral Solution (tofacitinib), sarilumab
Using tofacitinib together with sarilumab can increase the risk of serious and potentially fatal infections as well as some cancers. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food/lifestyle interactions
tofacitinib food/lifestyle
Applies to: Xeljanz Oral Solution (tofacitinib)
Consumer information for this interaction is not currently available.
MONITOR: Grapefruit juice may increase the plasma concentrations of tofacitinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Until more information is available, some authorities recommend avoiding consumption of grapefruit juice during tofacitinib therapy (Canada). Patients receiving tofacitinib therapy who ingest grapefruits or grapefruit juice should be monitored for adverse effects and undue fluctuations in plasma drug levels.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Humira
Humira is a tumor necrosis factor blocker used to treat many inflammatory conditions in adults ...
Advil
Advil (ibuprofen) reduces fever, pain and inflammation caused by headaches, toothaches, arthritis ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Deltasone
Deltasone is used for acute lymphocytic leukemia, adrenocortical insufficiency, allergic reactions ...
IBU
IBU is used for aseptic necrosis, back pain, chronic myofascial pain, costochondritis, diffuse ...
Kevzara
Kevzara (sarilumab) is used to treat rheumatoid arthritis, polymyalgia rheumatica and polyarticular ...
Rayos
Rayos (prednisone, delayed-release) is used to treat rheumatoid arthritis, polymyalgia rheumatica ...
Motrin IB
Motrin IB is used to reduce fever and treat pain or inflammation caused by headache, toothaches ...
Sterapred
Sterapred is used for acute lymphocytic leukemia, adrenocortical insufficiency, allergic reactions ...
Children's Motrin
Children's Motrin is used for fever, juvenile rheumatoid arthritis, pain, spondylolisthesis
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.