Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- cobicistat
- RizaFilm (rizatriptan)
Interactions between your drugs
rizatriptan cobicistat
Applies to: RizaFilm (rizatriptan), cobicistat
Coadministration with rizatriptan may alter the plasma concentrations of drugs that are primarily metabolized by CYP450 2D6. Rizatriptan has been shown to be a competitive inhibitor of CYP450 2D6 in vitro, but only at high, clinically irrelevant concentrations and a clinically significant inhibitory effect on CYP450 2D6 has not been demonstrated in clinical drug interaction studies. Based on these observations, rizatriptan may be administered with CYP450 2D6 substrates without the need for increased clinical monitoring
References (5)
- (2025) "Product Information. Symbravo (meloxicam-rizatriptan)." Axsome Therapeutics, Inc.
- (2020) "Product Information. Rizatriptan Benzoate (rizatriptan)." Exelan Pharmaceuticals Inc
- (2025) "Product Information. Rizatriptan (rizatriptan)." Organon Pharma (UK) Ltd
- (2018) "Product Information. Rizatriptan (rizatriptan)." Accel Pharma Inc
- (2024) "Product Information. Rizatriptan ODT (WGR) (rizatriptan)." GM Pharma International Pty Ltd
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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