Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- cobicistat
- mexiletine
Interactions between your drugs
mexiletine cobicistat
Applies to: mexiletine, cobicistat
MONITOR: Coadministration with cobicistat may increase the plasma concentrations of mexiletine. The proposed mechanism involves cobicistat inhibition of CYP450 2D6-mediated metabolism of mexiletine. The interaction has not been specifically studied, but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities if levels are significantly increased.
MANAGEMENT: Caution is advised if cobicistat must be used concomitantly with mexiletine. Pharmacologic response and plasma mexiletine levels should be monitored more closely whenever cobicistat is added to or withdrawn from therapy, and the mexiletine dosage adjusted as necessary.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2012) "Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofovir)." Gilead Sciences
- (2018) "Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenofovir)." Janssen Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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