Drug Interaction Report

Simeprevir may alter the blood levels and effects of tacrolimus in some patients. Contact your doctor if your symptoms worsen or you experience increased side effects during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.

Food significantly increases the absorption of simeprevir. You should take each dose of simeprevir with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.