Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Aubagio (teriflunomide)
- leflunomide
Interactions between your drugs
leflunomide teriflunomide
Applies to: leflunomide, Aubagio (teriflunomide)
CONTRAINDICATED: Teriflunomide is the active metabolite of leflunomide and has a similar toxicity profile as the parent drug.
MANAGEMENT: Concomitant use of leflunomide and teriflunomide is considered contraindicated due to the potential for increased toxicities such as peripheral neuropathy, serious liver injury, and bone marrow suppression.
References (1)
- (2012) "Product Information. Aubagio (teriflunomide)." Genzyme Corporation
Drug and food/lifestyle interactions
leflunomide food/lifestyle
Applies to: leflunomide
GENERALLY AVOID: The consumption of alcohol during therapy with leflunomide may potentiate the risk of liver injury. Leflunomide has been associated with hepatotoxicity, including elevated liver transaminases, hepatitis, jaundice/cholestasis, hepatic failure, and acute hepatic necrosis,
MANAGEMENT: Patients should be advised to avoid excessive alcohol use during leflunomide treatment.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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