Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dabigatran
- Zydelig (idelalisib)
Interactions between your drugs
dabigatran idelalisib
Applies to: dabigatran, Zydelig (idelalisib)
MONITOR: Coadministration with idelalisib may increase the serum concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter, such as dabigatran etexilate. Data suggest that idelalisib does not inhibit systemic P-gp at clinically relevant doses; however, it may have an effect on sensitive P-gp substrates in the gastrointestinal tract due to higher local concentrations after an oral dose.
MANAGEMENT: Caution and close monitoring are advised if idelalisib is prescribed in combination with orally administered P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever idelalisib is added to or withdrawn from therapy.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2014) "Product Information. Zydelig (idelalisib)." Gilead Sciences
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Eliquis
Eliquis (apixaban) is used to reduce the risk of stroke and systemic embolism in patients with ...
Xarelto
Xarelto (rivaroxaban) is a factor Xa inhibitor used to reduce the risk of blood clots and stroke in ...
Cosentyx
Cosentyx (secukinumab) is used to treat plaque psoriasis, psoriatic arthritis, ankylosing ...
Coumadin
Coumadin is used to prevent heart attacks, strokes, and blood clots in veins and arteries. Learn ...
Pradaxa
Pradaxa (dabigatran) is used to prevent stroke and blood clots in patients with atrial ...
Ecotrin
Ecotrin is used for angina, angina pectoris prophylaxis, ankylosing spondylitis, antiphospholipid ...
Jantoven
Jantoven is used for antiphospholipid syndrome, chronic central venous catheterization, deep vein ...
Rivaroxaban
Rivaroxaban is used for atrial fibrillation, cardiovascular risk reduction, congenital heart ...
Apixaban
Apixaban is used for deep vein thrombosis, deep vein thrombosis prophylaxis after hip replacement ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.