Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Bexxar Dosimetric (tositumomab)
- pegfilgrastim
Interactions between your drugs
pegfilgrastim tositumomab
Applies to: pegfilgrastim, Bexxar Dosimetric (tositumomab)
ADJUST DOSING INTERVAL: The safety and efficacy of recombinant human granulocyte colony-stimulating factors (rhG-CSF) administered simultaneously with cytotoxic agents, including cancer chemotherapy, have not been established. Theoretical concerns exist regarding their concomitant administration because hematopoietic growth factors stimulate myeloid cell proliferation while antineoplastic agents primarily target rapidly dividing cells.
MANAGEMENT: The prescribing information for pegfilgrastim, eflapegrastim, and efbemalenograstim alfa recommends that these products not be administered between 14 days before and 24 hours after antineoplastic agents.
References (3)
- (2002) "Product Information. Neulasta (pegfilgrastim)." Amgen
- (2022) "Product Information. Rolvedon (eflapegrastim)." Spectrum Pharmaceuticals Inc, 2
- (2023) "Product Information. Ryzneuta Prefilled Syringe (efbemalenograstim alfa)." Evive Biotech
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Rituxan
Rituxan infusion is used to treat certain leukemias and lymphomas and some non-cancer conditions ...
Cytoxan
Cytoxan is used for acute lymphocytic leukemia, acute nonlymphocytic leukemia, breast cancer ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Mitoxantrone
Mitoxantrone is used for acute nonlymphocytic leukemia, mantle cell lymphoma, multiple sclerosis ...
Bleomycin
Bleomycin is used for hodgkin's lymphoma, malignant pleural effusion, non-hodgkin's lymphoma ...
Fludarabine
Fludarabine is used for cancer, chronic lymphocytic leukemia, chronic myelogenous leukemia ...
Bendamustine
Bendamustine is used for chronic lymphocytic leukemia, multiple myeloma, non-hodgkin's lymphoma
Cytarabine
Cytarabine is used for acute myeloid leukemia, acute nonlymphocytic leukemia, chronic myelogenous ...
Vincristine
Vincristine is used for acute lymphocytic leukemia, acute myeloid leukemia, anaplastic ...
Cyclophosphamide
Cyclophosphamide is used for acute lymphocytic leukemia, acute nonlymphocytic leukemia, brain ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.