Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- clevidipine
- ginger / magnesium sulfate / pyridoxine
Interactions between your drugs
magnesium sulfate clevidipine
Applies to: ginger / magnesium sulfate / pyridoxine, clevidipine
MONITOR: Coadministration of intravenous magnesium and nifedipine may result in hypotension and neuromuscular blockade. Several cases have been reported in pregnant patients with preeclampsia. The mechanism is unknown. Other calcium channel blockers may also interact. The risk may be increased in patients with renal impairment.
MANAGEMENT: The cardiovascular, respiratory, and neurologic status of patients should be closely monitored if these drugs must be given concurrently.
References (7)
- Waisman GD, Mayorga LM, Camera MI, Vignolo CA, Martinotti A (1988) "Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia?" Am J Obstet Gynecol, 159, p. 308-9
- Snyder SW, Cardwell MS (1989) "Neuromuscular blockade with magnesium sulfate and nifedipine." Am J Obstet Gynecol, 161, p. 35-6
- (2002) "Product Information. Adalat (nifedipine)." Bayer
- Benami M, Giladi Y, Shalev E (1994) "The combination of magnesium sulphate and nifedipine - a cause of neuromuscular blockade." Br J Obstet Gynaecol, 101, p. 262-3
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Briggs GG, Yaffe SJ., Freeman RK (2011) "Drugs in Pregnancy and Lactation." Philadelphia, PA: Llippincott Williams & Wilkins
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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