Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Khindivi (hydrocortisone)
- metrizamide
Interactions between your drugs
hydrocortisone metrizamide
Applies to: Khindivi (hydrocortisone), metrizamide
CONTRAINDICATED: Coadministration of corticosteroids with iodinated contrast media by the intrathecal route may be associated with a high incidence of radiographic arachnoiditis. Meningitis and seizures may also occur.
MANAGEMENT: Intrathecal coadministration of corticosteroids with iodinated contrast media is considered contraindicated.
References (5)
- (2001) "Product Information. Amipaque (metrizamide)." Nycomed Inc
- (2001) "Product Information. Osmovist 240 (iotrolan)." Berlex Canada Inc
- (2007) "Product Information. Omnipaque 180 (iohexol)." Amersham Health
- (2007) "Product Information. Isovue-M-200 (iopamidol)." Bracco Diagnostics Inc
- Nelson DA, Landau WM (2001) "Intraspinal steroids: history, efficacy, accidentality, and controversy with review of United States Food and Drug Administration reports." J Neurol Neurosurg Psychiatry, 70, p. 433-43
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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