Drug Interaction Report

Talk to your doctor before using tretinoin together with aprotinin. Combining these medications may increase the risk of blood clots, which can lead to serious conditions such as stroke, heart attack, heart failure, collapse, and kidney failure. The risk is greatest during the first month of treatment with tretinoin. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.