Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- tenofovir disoproxil
- Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
Interactions between your drugs
tenofovir velpatasvir
Applies to: tenofovir disoproxil, Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
Velpatasvir may increase the blood levels of tenofovir. This may increase side effects such as nausea, diarrhea, rash, and kidney problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
velpatasvir voxilaprevir
Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir), Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
Velpatasvir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
voxilaprevir food
Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
Food may help the absorption of voxilaprevir. You should take this medication with food as directed.
tenofovir food
Applies to: tenofovir disoproxil
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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