Drug Interaction Report

Coadministration of mavorixafor with tamsulosin is not recommended. Mavorixafor is a strong inhibitor of a pathway the body uses to process tamsulosin. In most cases this pathway is used to eliminate the medication, so blocking this pathway could lead to a significant increase in side effects. In some cases, this pathway is used to activate the medication (e.G., codeine), so blocking this pathway would make such medications less effective in treating your condition. Speak with your doctor or healthcare provider if you have any questions. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Mavorixafor should be taken on an empty stomach after an overnight fast, 30 minutes before food. Do not consume grapefruit products during treatment with mavorixafor unless otherwise directed by your doctor. Grapefruit juice can increase the blood levels and adverse effects of mavorixafor, increasing the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which can result in irregular heartbeats that can be life-threatening. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. Speak with your doctor or healthcare provider if you have any questions. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may affect the intestinal absorption of tamsulosin. You should take tamsulosin approximately one-half hour following the same meal each day to ensure steady absorption and blood levels of the drug.