Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- rifabutin
- Sesquient (fosphenytoin)
Interactions between your drugs
rifabutin fosphenytoin
Applies to: rifabutin, Sesquient (fosphenytoin)
MONITOR: Rifampin and rifabutin may decrease plasma concentrations and effectiveness of hydantoins by inducing their CYP450 hepatic metabolism.
MANAGEMENT: Close observation for clinical and laboratory evidence of altered hydantoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control. Dosage should be increased as necessary.
References (3)
- Venkatesan K (1992) "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet, 22, p. 47-65
- Abajo FJ (1988) "Phenytoin interaction with rifampicin." Br Med J, 297, p. 1048
- Kay L, Kampmann JP, Svedsen L, et al. (1985) "Influence of rifampicin and isoniazid on the kinetics of phenytoin." Br J Clin Pharmacol, 20, p. 323-6
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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