Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- morphine liposomal
- Provera (medroxyprogesterone)
Interactions between your drugs
medroxyPROGESTERone morphine liposomal
Applies to: Provera (medroxyprogesterone), morphine liposomal
Oral contraceptives induce glucuronidation and may decrease plasma concentrations of morphine, diamorphine, and other opioids. Oral contraceptives may influence opioid analgesic effects and opioid dosage may need to be adjusted. However, the clinical significance of this interaction has not been established.
References (5)
- Shenfield GM, Griffin JM (1991) "Clinical pharmacokinetics of contraceptive steroids: an update." Clin Pharmacokinet, 20, p. 15-37
- (2001) "Product Information. NuvaRing (ethinyl estradiol-etonogestrel)." Organon
- Cerner Multum, Inc. (2015) "Canadian Product Information."
- (2022) "Product Information. VyLibra (28 Day) (ethinyl estradiol-norgestimate)." Afaxys Inc.
- Ribeiro-Dasilva MC, Shinal RM, Glover T, Williams RS, Staud R, Riley JL 3rd, Fillingim RB (2011) "Evaluation of menstrual cycle effects on morphine and pentazocine analgesia" Pain, 152, p. 614-622
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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