Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- miconazole
- Mycobutin (rifabutin)
Interactions between your drugs
miconazole rifabutin
Applies to: miconazole, Mycobutin (rifabutin)
Concomitant administration of oral miconazole may increase the plasma levels of rifabutin and the risk of adverse effects. The possible mechanism of this interaction is inhibition of CYP450 3A4. In addition, rifabutin may increase the metabolism and decrease the plasma levels of miconazole due to induction of CYP450 enzymes. The clinical significance of this interaction is unknown because systemic absorption from buccal and oral gel dosage forms is significantly lower than with parenteral administration.
References (3)
- (2001) "Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2010) "Product Information. ORAVIG (miconazole)." Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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