Drug Interaction Report

Some of the medication in roflumilast topical may be absorbed into the bloodstream following local application. It is possible that use of methoxsalen may further increase blood levels of the medication by interfering with its clearance from your body. You may be more likely to experience side effects of roflumilast topical such as diarrhea, headache, insomnia, nausea, upper respiratory tract infection, or urinary tract infection. Let your doctor know if side effects become excessive or intolerable. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Methoxsalen should be administered with food or milk. This may make it easier for your body to tolerate the medication. Avoid eating or coming in contact with limes, figs, parsley, parsnips, rue (Ruta graveolens), mustard, carrots and celery. This can increase the risk of photosensitivity and cause your skin to burn more easily. Avoid prolonged exposure to sunlight, sunlamps, or tanning beds. Methoxsalen make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use a sunscreen if you must be in the sun. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.