Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- ambrisentan
- Lopid (gemfibrozil)
Interactions between your drugs
gemfibrozil ambrisentan
Applies to: Lopid (gemfibrozil), ambrisentan
ADJUST DOSE: Coadministration with gemfibrozil may increase the plasma concentrations of drugs that are substrates of the organic anion transporting polypeptide (OATP) 1B1 transporter. The mechanism is decreased clearance due to inhibition of OATP 1B1-mediated hepatic uptake by gemfibrozil and its metabolite, gemfibrozil 1-O-beta-glucuronide. The clinical relevance of this interaction is unknown.
MANAGEMENT: A dosage reduction of OATP 1B1 substrates may be required when used with gemfibrozil. Clinical and laboratory monitoring may be appropriate for some drugs whenever gemfibrozil is added to or withdrawn from therapy.
References (2)
- (2007) "Product Information. Lasix (furosemide)." sanofi-aventis
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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