Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- amantadine
- Namenda (memantine)
Interactions between your drugs
amantadine memantine
Applies to: amantadine, Namenda (memantine)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of memantine with other N-methyl-D-aspartate (NMDA) antagonists such as amantadine, ketamine or dextromethorphan may result in additive CNS effects. Data are limited and the clinical significance is unknown.
MANAGEMENT: Caution and clinical monitoring are advised when memantine is coadministered with other N-methyl-D-aspartate (NMDA) antagonists. If coadministration is required, close clinical monitoring for adverse effects (e.g., sedation, psychosis) is advised and dose adjustments may be required, particularly when memantine is initiated or withdrawn from therapy. Individual product labeling should be consulted. Some authorities recommend avoiding the combination of memantine with other NMDA antagonists.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
NMDA antagonists
Therapeutic duplication
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'NMDA antagonists' category:
- amantadine
- Namenda (memantine)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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