Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amantadine
- FluMist Quadrivalent (influenza virus vaccine, live)
Interactions between your drugs
amantadine influenza virus vaccine, live
Applies to: amantadine, FluMist Quadrivalent (influenza virus vaccine, live)
ADJUST DOSING INTERVAL: Antiviral agents that are active against influenza A and/or B viruses may conceivably interfere with the immunogenicity of live influenza virus vaccine by inhibiting the replication of vaccine virus. However, the potential for interaction has not been evaluated.
MANAGEMENT: Live influenza virus vaccine should not be administered until at least 48 hours after the cessation of antiviral therapy. Antiviral agents should not be administered until two weeks after immunization with live influenza virus vaccine unless medically indicated. If antiviral agents and live influenza virus vaccine are administered concomitantly, revaccination should be considered when appropriate. The product labeling for zanamivir recommends waiting 24 hours after cessation of the drug before administration of live influenza virus vaccine.
References (9)
- (2022) "Product Information. Flumadine (riMANTAdine)." Forest Pharmaceuticals
- (2001) "Product Information. Relenza (zanamivir)." Glaxo Wellcome
- (2001) "Product Information. Tamiflu (oseltamivir)." Roche Laboratories
- (2022) "Product Information. FluMist (influenza virus vaccine, live)." Medimmune Inc
- (2022) "Product Information. Influenza Virus Vaccine, H1N1, Live (influenza virus vaccine, H1N1, live)." Medimmune Inc
- (2015) "Product Information. Rapivab (peramivir)." BioCryst Pharmaceuticals Inc
- (2015) "Product Information. FluMist Quadrivalent (influenza virus vaccine, live)." AstraZeneca Pharma Inc
- (2018) "Product Information. Xofluza (baloxavir marboxil)." Genentech
- Grohskopf LA, Sokolow LZ, Broder KR, Walter EB, Fry AM, Jernigan DB (2018) "Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices-United States, 2018-19 influenza season." MMWR Recomm Rep, 67, p. 1-20
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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