Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Astero (lidocaine topical)
- bcg vaccine
Interactions between your drugs
lidocaine topical BCG vaccine
Applies to: Astero (lidocaine topical), bcg vaccine
Topical lidocaine has bactericidal and antiviral properties when used in concentrations above 0.5%. Clinical studies evaluating the impact of topical lidocaine on intradermal vaccinations are unavailable. However, the efficacy of live vaccines administered intradermally (e.g., BCG vaccine) may be diminished when used concomitantly with topical lidocaine formulations that are applied directly over the site of vaccine administration.
References (3)
- (2023) "Product Information. LMX 4 (lidocaine topical)." Ferndale Pharmaceuticals Ltd
- liu x, Zheng F, Tian L, li t, Zhang Z, Ren Z, Chen X, Chen W, li k, Sheng J (2023) "Lidocaine inhibits influenza a virus replication by up-regulating IFN-alpha4 via TBK1-IRF7 and JNK-AP1 signaling pathways" Int Immunopharmacol, 115, p. 1-9
- olsen km, Peddicord TE, Campbell GD, rupp me (2000) "Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid" J Antimicrob Chemother, 45, p. 217-9
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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