Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- isotretinoin
- Tepylute (thiotepa)
Interactions between your drugs
thiotepa ISOtretinoin
Applies to: Tepylute (thiotepa), isotretinoin
Coadministration of thiotepa may increase plasma concentrations of drugs that are primarily metabolized by CYP450 2B6. Thiotepa has been shown to be a weak inhibitor of CYP450 2B6 in vitro, although drug interactions studies are not available, and the clinical significance is unknown. Product labeling for the specific CYP450 2B6 substrate should be consulted for additional recommendations and monitoring for increased adverse effects when used concomitantly with thiotepa may be warranted.
References (4)
- (2023) "Product Information. Thiotepa (thiotepa)." Meitheal Pharmaceuticals Inc.
- (2023) "Product Information. Tepadina (thiotepa)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 3
- (2022) "Product Information. Thiotepa (thiotepa)." MSN Laboratories Europe Ltd
- (2021) "Product Information. Tepadina (thiotepa)." Adienne SA
Drug and food/lifestyle interactions
ISOtretinoin food/lifestyle
Applies to: isotretinoin
GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.
MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.
References (1)
- (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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