Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Bebulin (factor ix complex)
- coagulation factor Xa
Interactions between your drugs
factor IX complex coagulation factor Xa
Applies to: Bebulin (factor ix complex), coagulation factor Xa
GENERALLY AVOID: The safety of andexanet alfa (recombinant coagulation factor Xa) has not been evaluated in patients who received prothrombin complex concentrates, recombinant factor VIIa, or whole blood within seven days prior to the bleeding event, as they were excluded from clinical trials.
MANAGEMENT: Pro-coagulant factor treatments (e.g., 3- or 4-factor prothrombin complex concentrates (PCCs), activated PCC, recombinant factor VIIa, fresh frozen plasma) and whole blood should be avoided during treatment with andexanet alfa unless absolutely required.
References (3)
- (2022) "Product Information. Andexxa (coagulation factor Xa)." Portola Pharmaceuticals
- (2022) "Product Information. Ondexxya (coagulation factor Xa)." AstraZeneca UK Ltd
- (2023) "Product Information. Andexxa (andexanet alfa (factor Xa))." AstraZeneca Pty Ltd
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Cyklokapron
Cyklokapron is used for bleeding disorder, factor ix deficiency, hemophilia a
Caplyta
Caplyta is used to treat schizophrenia or depression associated with bipolar disorder. It is taken ...
Idelvion
Idelvion (coagulation factor ix recombinant, albumin fusion protein) is a long-acting, injectable ...
Alprolix
Alprolix is used in hemophilia B to help control and prevent bleeding, it is a coagulation Factor ...
BeneFix
BeneFix (coagulation factor IX) is a once-weekly, injectable, treatment for hemophilia B that may ...
Rebinyn
Rebinyn (glycopegylated coagulation factor IX [recombinant]) is an injectable, long-lasting, human ...
Profilnine
Profilnine is used for factor ix deficiency, factor vii deficiency, hemophilia a with inhibitors ...
Coagulation factor ix
Coagulation factor ix is used for factor ix deficiency, hemophilia b
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Further information
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