Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- etoposide
- vincristine
Interactions between your drugs
etoposide vinCRIStine
Applies to: etoposide, vincristine
Concurrent administration of vincristine and etoposide may lead to an earlier onset and/or an increased severity of side effects. The mechanism is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and etoposide are used concomitantly, caution and close observation are advised.
References (2)
- Zhou-Pan XR, Seree E, Zhou XJ, et al. (1993) "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res, 53, p. 5121-6
- (2001) "Product Information. Oncovin (vincristine)." Lilly, Eli and Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Mitotic inhibitors
Therapeutic duplication
The recommended maximum number of medicines in the 'mitotic inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'mitotic inhibitors' category:
- etoposide
- vincristine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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