Aleve-D Sinus & Headache and Alcohol/Food Interactions
There are 5 alcohol/food/lifestyle interactions with Aleve-D Sinus & Headache (naproxen / pseudoephedrine).
pseudoephedrine Caffeine
Moderate Drug Interaction
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
- Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
- "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc PROD (2001):
- "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals PROD (2001):
- "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals PROD (2001):
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc (2001):
- "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company (2002):
naproxen Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using naproxen together with ethanol. Do not drink alcohol while taking naproxen. Alcohol can increase your risk of stomach bleeding caused by naproxen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
NSAIDs - fluid retention
Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
- "Product Information. Nalfon (fenoprofen)." Xspire Pharma PROD (2002):
- "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
- "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories PROD (2002):
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
- "Product Information. Anaprox (naproxen)." Roche Laboratories PROD (2006):
- "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
- "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical PROD (2001):
- "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
- "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
- "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim PROD (2001):
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
naproxen - sodium
Anaprox and Anaprox DS (brands of naproxen sodium) contain 25 mg and 50 mg of sodium per tablet (approximately 1 mEq/250 mg naproxen), respectively, and Naprosyn suspension contains 39 mg per teaspoonful (approximately 1.5 mEq/125 mg naproxen). The sodium content should be considered when these products are used in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
References
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
- "Product Information. Anaprox (naproxen)." Roche Laboratories PROD (2006):
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
NSAIDs - hypertension
Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. NSAIDs should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.
References
- "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
- "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
- "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
- "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
- "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
- "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
- "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
- "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc (2012):
- "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
Aleve-D Sinus & Headache drug interactions
There are 567 drug interactions with Aleve-D Sinus & Headache (naproxen / pseudoephedrine).
Aleve-D Sinus & Headache disease interactions
There are 19 disease interactions with Aleve-D Sinus & Headache (naproxen / pseudoephedrine) which include:
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- cardiovascular disease
- sodium
- anemia
- heart failure
- hepatotoxicity
- hyperkalemia
- hypertension
- platelet aggregation inhibition
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
More about Aleve-D Sinus & Headache (naproxen / pseudoephedrine)
- Aleve-D Sinus & Headache consumer information
- Check interactions
- Compare alternatives
- Reviews (1)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.