Guaifenex PPA 75 (guaifenesin / phenylpropanolamine) and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Guaifenex PPA 75 (guaifenesin / phenylpropanolamine):
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate the central nervous system and cardiovascular effects of centrally-acting appetite suppressants. In one study, concurrent administration of methamphetamine (30 mg intravenously) and ethanol (1 gm/kg orally over 30 minutes) increased heart rate by 24 beats/minute compared to methamphetamine alone. This increases cardiac work and myocardial oxygen consumption, which may lead to more adverse cardiovascular effects than either agent alone. Subjective effects of ethanol were diminished in the eight study subjects, but those of methamphetamine were not affected. The pharmacokinetics of methamphetamine were also unaffected except for a decrease in the apparent volume of distribution at steady state.
MANAGEMENT: Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease. Patients should be counselled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68
- "Product Information. Didrex (benzphetamine)" Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Suprenza (phentermine)." Akrimax Pharmaceuticals, Cranford, NJ.
Guaifenex PPA 75 (guaifenesin / phenylpropanolamine) drug interactions
There are 181 drug interactions with Guaifenex PPA 75 (guaifenesin / phenylpropanolamine)
Guaifenex PPA 75 (guaifenesin / phenylpropanolamine) disease interactions
There are 5 disease interactions with Guaifenex PPA 75 (guaifenesin / phenylpropanolamine) which include:
More about Guaifenex PPA 75 (guaifenesin / phenylpropanolamine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Drug class: upper respiratory combinations
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Drug Interaction Classification
|No interaction information available.|