Guaifenesin / Phenylpropanolamine Dosage

Usual Adult Dose for Cough and Nasal Congestion

5 mL to 10 mL (100 mg-12.5 mg/5 mL) orally every 4 hours.

-or-

20 mL (50 mg-6.25 mg/5 mL) orally every 4 hours.

-or-

Extended release: 1 tablet (40 mg to 50 mg phenylpropanolamine) orally every 12 hours.

Maximum is 150 mg phenylpropanolamine or 2.4 grams of guaifenesin/day.

Usual Pediatric Dose for Cough and Nasal Congestion

6 to 12 years:

1 mL (50 mg-6.25 mg/mL) orally every 4 hours. (Drops - Note concentration).

-or-

1 mL (30 mg-6.25 mg/mL) orally every 4 hours. (Drops - Note concentration).

-or-

5 mL (100 mg-6.25 mg/5 mL) orally every 4 hours.

Maximum is 75 mg phenylpropanolamine or 1.2 grams of guaifenesin/day.
Over 12 years:

10 mL (100 mg-6.25 mg/5 mL) orally every 4 hours.

Maximum is 150 mg phenylpropanolamine or 2.4 grams of guaifenesin/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Phenylpropanolamine is eliminated by the kidney and may accumulate in patients with renal dysfunction. Patients with renal dysfunction should be monitored for signs and symptoms of toxicity when using phenylpropanolamine.

Precautions

Check concentration.

Dialysis

Data not available

Other Comments

In November 2000, the Food and Drug Administration (FDA), in response to reports of increased risk of hemorrhagic stroke, requested that all drug companies discontinue marketing products containing phenylpropanolamine.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer