Epoetin beta-methoxy polyethylene glycol and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with epoetin beta-methoxy polyethylene glycol.
Epoetin Beta-Methoxy Polyethylene Glycol High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
erythropoiesis-stimulating agents - hypertension
The use of erythropoiesis-stimulating agents is contraindicated in patients with uncontrolled hypertension. These agents may cause blood pressure to rise. Hypertensive encephalopathy and seizures have been observed in patients with chronic renal failure treated with these agents. Blood pressure should be adequately controlled prior to initiation of therapy, and monitored closely during treatment. Aggressive antihypertensive measures may be necessary, particularly early on in treatment when the hematocrit is increasing. It is recommended to reduce or withhold the use of these agents if blood pressure becomes difficult to control.
References (9)
- Bennett WM (1991) "Side effects of erythropoietin therapy." Am J Kidney Dis, 18, p. 84-6
- Eschbach JW, Abdulhadi MH, Browne JK, Delano BG, Downing MR, Egrie JC, Evans RW, Friedman EA, Graber SE, Haley NR, et al. (1989) "Recombinant human erythropoietin in anemic patients with end-stage renal disease. Results of a phase III multicenter clinical trial." Ann Intern Med, 111, p. 992-1000
- Raine AE (1988) "Hypertension, blood viscosity, and cardiovascular morbidity in renal failure: implications of erythropoietin therapy." Lancet, 1, p. 97-100
- Buckner FS, Eschbach JW, Haley NR, Davidson RC, Adamson JW (1990) "Hypertension following erythropoietin therapy in anemic hemodialysis patients." Am J Hypertens, 3, p. 947-55
- (2002) "Product Information. Epogen (epoetin alfa)." Amgen
- (2002) "Product Information. Procrit (epoetin alfa)." Ortho Biotech Inc
- Singbartl G (1994) "Adverse events of erythropoietin in long-term and in acute short-term treatment." Clin Investig, 72, s36-43
- (2001) "Product Information. Aranesp (darbepoetin alfa)." Amgen
- (2007) "Product Information. Mircera (epoetin beta-methoxy polyethylene glycol)." Vifor International Ltd c/o MCT
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Epoetin beta-methoxy polyethylene glycol drug interactions
There are 23 drug interactions with epoetin beta-methoxy polyethylene glycol.
Epoetin beta-methoxy polyethylene glycol disease interactions
There are 4 disease interactions with epoetin beta-methoxy polyethylene glycol which include:
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- During pregnancy
- Drug class: recombinant human erythropoietins
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.