Dimethyl fumarate and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with dimethyl fumarate.
Dimethyl Fumarate Food
Minor Food Interaction
Food does not significantly affect the oral bioavailability of dimethyl fumarate. Administration of dimethyl fumarate with a high-fat, high-calorie meal did not affect the systemic exposure (AUC) to its active metabolite, monomethyl fumarate (MMF), but decreased its peak plasma concentration (Cmax) by 40% and prolonged the time to reach peak concentration (Tmax) from 2.0 hours to 5.5 hours. In the study, the incidence of flushing was reduced by approximately 25% in the fed state. Dimethyl fumarate may be taken with or without food; however, taking it with food may help reduce flushing.
References (1)
- (2013) "Product Information. Tecfidera (dimethyl fumarate)." Biogen
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Dimethyl fumarate drug interactions
There are 641 drug interactions with dimethyl fumarate.
Dimethyl fumarate disease interactions
There are 5 disease interactions with dimethyl fumarate which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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