Alka-Seltzer Plus Cold and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine).
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
Alka-Seltzer Plus Cold drug interactions
There are 528 drug interactions with Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine).
Alka-Seltzer Plus Cold disease interactions
There are 11 disease interactions with Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine) which include:
- liver disease
- cardiovascular disease
- anticholinergic effects
- renal/liver disease
More about Alka-Seltzer Plus Cold (acetaminophen / chlorpheniramine / phenylephrine)
- Alka-Seltzer Plus Cold consumer information
- Check interactions
- Reviews (10)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.