Pembrolizumab Drug Interactions
Currently displaying a list of 589 drugs known to interact with pembrolizumab.
- 3 major drug interactions
- 586 moderate drug interactions
Medications known to interact with pembrolizumab
Note: Showing generic names only.
A
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- acetaminophen
- acetohydroxamic acid
- adagrasib
- adenovirus vaccine
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- afatinib
- albendazole
- aldesleukin
- alectinib
- alefacept
- alfentanil
- alpelisib
- altretamine
- amikacin
- amikacin liposome
- aminosalicylic acid
- amivantamab
- amoxicillin
- ampicillin
- anakinra
- anifrolumab
- anisindione
- anthrax vaccine adsorbed
- anti-thymocyte globulin (rabbit)
- apomorphine
- apremilast
- arsenic trioxide
- asciminib
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atovaquone
- auranofin
- aurothioglucose
- avacopan
- avapritinib
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- azithromycin
- aztreonam
B
- bacampicillin
- bacitracin
- baricitinib
- basiliximab
- bcg
- bcg vaccine
- beclomethasone
- bedaquiline
- belantamab mafodotin
- belatacept
- belimumab
- belinostat
- belumosudil
- bendamustine
- benralizumab
- benznidazole
- betamethasone
- bexarotene
- bimekizumab
- bleomycin
- blinatumomab
- bortezomib
- bosutinib
- brentuximab
- brexucabtagene autoleucel
- brigatinib
- brodalumab
- budesonide
- buprenorphine
- busulfan
- butorphanol
C
- cabazitaxel
- cabozantinib
- calaspargase pegol
- canakinumab
- capecitabine
- capmatinib
- capreomycin
- carbamazepine
- carbenicillin
- carboplatin
- carfilzomib
- carmustine
- cefaclor
- cefadroxil
- cefamandole
- cefazolin
- cefdinir
- cefditoren
- cefepime
- cefiderocol
- cefixime
- cefmetazole
- cefonicid
- cefoperazone
- cefotaxime
- cefotetan
- cefoxitin
- cefpodoxime
- cefprozil
- ceftaroline
- ceftazidime
- ceftibuten
- ceftizoxime
- ceftobiprole medocaril
- ceftriaxone
- cefuroxime
- cephalexin
- cephalothin
- cephapirin
- cephradine
- ceritinib
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chlorambucil
- chloramphenicol
- cholera vaccine
- cholera vaccine, live
- ciltacabtagene autoleucel
- cinoxacin
- ciprofloxacin
- cisplatin
- clarithromycin
- clavulanate
- clindamycin
- clofarabine
- clofazimine
- cloxacillin
- cobimetinib
- codeine
- colistimethate
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- crovalimab
- cyclophosphamide
- cycloserine
- cyclosporine
- cytarabine
- cytarabine liposomal
D
- dabrafenib
- dacarbazine
- daclizumab
- dacomitinib
- dactinomycin
- dalbavancin
- danicopan
- dapsone
- daptomycin
- daratumumab
- dasatinib
- daunorubicin
- daunorubicin liposomal
- decitabine
- deflazacort
- delafloxacin
- demeclocycline
- dengue vaccine
- denileukin diftitox
- denosumab
- dexamethasone
- dexlansoprazole
- dexrazoxane
- dezocine
- dicloxacillin
- dicumarol
- dimethyl fumarate
- dinutuximab
- dirithromycin
- diroximel fumarate
- docetaxel
- doripenem
- doxorubicin
- doxorubicin liposomal
- doxycycline
- dupilumab
- duvelisib
E
- eculizumab
- efalizumab
- efgartigimod alfa
- eflornithine
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- emapalumab
- enfortumab vedotin
- enoxacin
- entrectinib
- epcoritamab
- epirubicin
- eravacycline
- eribulin
- ertapenem
- erythromycin
- esomeprazole
- ethambutol
- ethionamide
- ethotoin
- etoposide
- etrasimod
- everolimus
F
- fam-trastuzumab deruxtecan
- fedratinib
- felbamate
- fentanyl
- fexinidazole
- fidaxomicin
- floxuridine
- flucytosine
- fludarabine
- fludrocortisone
- fluorouracil
- fosfomycin
- fruquintinib
- furazolidone
- futibatinib
G
- gatifloxacin
- gemcitabine
- gemifloxacin
- gemtuzumab
- gentamicin
- gilteritinib
- givinostat
- glofitamab
- gold sodium thiomalate
- grepafloxacin
- guanidine
- guselkumab
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- heroin
- human papillomavirus vaccine
- hydrocodone
- hydrocortisone
- hydromorphone
- hydroxyurea
I
- ibritumomab
- ibrutinib
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- imetelstat
- inavolisib
- inebilizumab
- infigratinib
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfa-n3
- interferon alfacon-1
- interferon gamma-1b
- iobenguane I 131
- iodine i 131 tositumomab
- iptacopan
- irinotecan
- irinotecan liposomal
- isatuximab
- isoniazid
- ixabepilone
- ixazomib
- ixekizumab
J
K
L
- lansoprazole
- larotrectinib
- lefamulin
- lenalidomide
- levamisole
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levorphanol
- lifileucel
- lincomycin
- linezolid
- lisocabtagene maraleucel
- lomefloxacin
- lomustine
- loncastuximab tesirine
- loracarbef
- lorlatinib
- lurbinectedin
- lutetium lu 177 dotatate
- lutetium lu 177 vipivotide tetraxetan
- lyme disease vaccine
- lymphocyte immune globulin, anti-thy (equine)
M
- measles virus vaccine
- mechlorethamine
- melphalan
- melphalan flufenamide
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- meperidine
- mepolizumab
- mercaptopurine
- meropenem
- methadone
- methenamine
- methicillin
- methotrexate
- methylprednisolone
- metronidazole
- mezlocillin
- midostaurin
- minocycline
- mirikizumab
- mirvetuximab soravtansine
- mitomycin
- mitoxantrone
- mixed respiratory vaccine
- mogamulizumab
- momelotinib
- monomethyl fumarate
- morphine
- morphine liposomal
- mosunetuzumab
- moxetumomab pasudotox
- moxifloxacin
- mumps virus vaccine
- muromonab-cd3
- mycophenolate mofetil
- mycophenolic acid
N
- nadofaragene firadenovec
- nafcillin
- nalbuphine
- nalidixic acid
- naxitamab
- nelarabine
- neomycin
- netilmicin
- nilotinib
- niraparib
- nitrofurantoin
- norfloxacin
- novobiocin
O
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- ofloxacin
- olaparib
- olaratumab
- oliceridine
- omacetaxine
- omadacycline
- omalizumab
- omeprazole
- opium
- oritavancin
- osimertinib
- oxacillin
- oxaliplatin
- oxycodone
- oxymorphone
- oxytetracycline
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- panobinostat
- pantoprazole
- paromomycin
- pazopanib
- pegaspargase
- pegcetacoplan
- peginterferon alfa-2a
- peginterferon alfa-2b
- pemetrexed
- pemigatinib
- penicillamine
- penicillin g benzathine
- penicillin g potassium
- penicillin g sodium
- penicillin v potassium
- pentamidine
- pentazocine
- pentostatin
- pertussis, acellular
- pexidartinib
- phenylbutazone
- piperacillin
- pirtobrutinib
- plague vaccine
- plazomicin
- plicamycin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- polatuzumab vedotin
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- polymyxin b
- pomalidomide
- ponatinib
- pozelimab
- pralatrexate
- pralsetinib
- prednisolone
- prednisone
- pretomanid
- primaquine
- procainamide
- procaine penicillin
- procarbazine
- promazine
- propoxyphene
- pyrazinamide
Q
R
- rabeprazole
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- ravulizumab
- regorafenib
- remifentanil
- reslizumab
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifamycin
- rifapentine
- rifaximin
- rilonacept
- risankizumab
- ritlecitinib
- rituximab
- roflumilast
- romidepsin
- ropeginterferon alfa-2b
- rotavirus vaccine
- rozanolixizumab
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- ruxolitinib
S
- sacituzumab govitecan
- samarium sm 153 lexidronam
- sarecycline
- sarilumab
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- satralizumab
- secnidazole
- secukinumab
- selinexor
- selumetinib
- siltuximab
- sipuleucel-T
- sirolimus
- sirolimus protein-bound
- smallpox and mpox vaccine
- smallpox vaccine
- sotorasib
- sparfloxacin
- spectinomycin
- spesolimab
- staphage lysate (spl)
- streptomycin
- streptozocin
- sufentanil
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfamethoxazole
- sulfisoxazole
- sunitinib
- sutimlimab
T
- tacrolimus
- tafasitamab
- tagraxofusp
- talazoparib
- talimogene laherparepvec
- talquetamab
- tapentadol
- tarlatamab
- tazemetostat
- tazobactam
- tebentafusp
- teclistamab
- tedizolid
- telavancin
- telithromycin
- temozolomide
- temsirolimus
- teniposide
- teplizumab
- tepotinib
- tetanus toxoid
- tetracycline
- thalidomide
- thioguanine
- thiotepa
- ticarcillin
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tigecycline
- tildrakizumab
- tisagenlecleucel
- tisotumab vedotin
- tobramycin
- tocilizumab
- topotecan
- tositumomab
- trabectedin
- tramadol
- trastuzumab
- treosulfan
- tretinoin
- triamcinolone
- triamcinolone ophthalmic
- trimethoprim
- trimetrexate
- troleandomycin
- trovafloxacin
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vamorolone
- vancomycin
- varicella virus vaccine
- vedolizumab
- venetoclax
- vilobelimab
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- vonoprazan
- vorinostat
W
Y
Z
- zanidatamab
- zanubrutinib
- zidovudine
- zilucoplan
- ziv-aflibercept
- zoster vaccine live
- zoster vaccine, recombinant
Pembrolizumab disease interactions
There are 9 disease interactions with pembrolizumab which include:
- immune system disorder
- HSCT
- myasthenia gravis
- organ transplant
- colitis
- hepatic impairment
- multiple myeloma
- pneumonitis
- thyroid disease
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More about pembrolizumab
- pembrolizumab consumer information
- Check interactions
- Compare alternatives
- Reviews (281)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
