Drug Interactions between eplerenone and Vitoxapap
This report displays the potential drug interactions for the following 2 drugs:
- eplerenone
- Vitoxapap (acetaminophen/phenyltoloxamine)
Interactions between your drugs
No interactions were found between eplerenone and Vitoxapap. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
eplerenone
A total of 371 drugs are known to interact with eplerenone.
- Eplerenone is in the following drug classes: aldosterone receptor antagonists, potassium-sparing diuretics.
- Eplerenone is used to treat the following conditions:
Vitoxapap
A total of 384 drugs are known to interact with Vitoxapap.
- Vitoxapap is in the drug class analgesic combinations.
- Vitoxapap is used to treat the following conditions:
Drug and food interactions
eplerenone food
Applies to: eplerenone
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with grapefruit juice may increase the plasma concentrations of eplerenone. The primary mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Inhibition of hepatic CYP450 3A4 may also contribute. In drug interaction studies, administration of a single 100 mg dose of eplerenone in combination with grapefruit juice resulted in a 25% increase in eplerenone systemic exposure (AUC). High blood levels of eplerenone can increase the risk of side effects including hyperkalemia. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition.
MANAGEMENT: It may be advisable for patients to avoid the consumption of grapefruit, grapefruit juice, or supplements that contain grapefruit during treatment with eplerenone.
References
- "Product Information. Inspra (eplerenone)." Searle (2002):
- "Product Information. Eplerenone (eplerenone)." MSN Laboratories Europe Ltd (2021):
- "Product Information. Eplerenone (Apotex) (eplerenone)." Apotex Pty Ltd (2023):
acetaminophen food
Applies to: Vitoxapap (acetaminophen / phenyltoloxamine)
Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenyltoloxamine food
Applies to: Vitoxapap (acetaminophen / phenyltoloxamine)
Alcohol can increase the nervous system side effects of phenyltoloxamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with phenyltoloxamine. Do not use more than the recommended dose of phenyltoloxamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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