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Dextromethorphan / guaifenesin / pseudoephedrine Drug Interactions

A total of 839 drugs are known to interact with dextromethorphan / guaifenesin / pseudoephedrine.

  • 169 major drug interactions
  • 657 moderate drug interactions
  • 13 minor drug interactions

Show all medications in the database that may interact with dextromethorphan / guaifenesin / pseudoephedrine.

Check for interactions

Type in a drug name to check for interactions with dextromethorphan / guaifenesin / pseudoephedrine.

Most frequently checked interactions

View interaction reports for dextromethorphan / guaifenesin / pseudoephedrine and the medicines listed below.

  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Benadryl (diphenhydramine)
  • Biaxin (clarithromycin)
  • Carafate (sucralfate)
  • Celexa (citalopram)
  • Combivent (albuterol / ipratropium)
  • Depakote (divalproex sodium)
  • dextromethorphan / guaifenesin (Mucinex DM, Robitussin Cough + Chest Congestion DM, Tussin DM, Guaifenex DM, Robafen DM, Mucinex Children's Cough, Coricidin HBP Chest Congestion & Cough, Delsym Cough+ Chest Congestion DM, Zyncof, Mucinex DM Maximum Strength, Diabetic Tuss DM, Iophen DM, Biocotron, Tussin DM Max, Vicks DayQuil Mucus Control DM, Cough Formula-DM, Iophen DM NR, PediaCare Cough & Congestion, Broncotron, Siltussin DM, Phlemex, Cheracol D Cough, Tussi-Organidin DM NR, Tussin Cough, G-Tron, Cofex-DM, Creo-Terpin, Guaifenesin DM, Chest Congestion Relief DM, Humibid DM Pediatric, Ambi 1000/55, Guiatussin-DM, Guiatuss DM, Benylin Expectorant, Vicks Pediatric Formula 44e Cough & Chest Congestion Relief, Anti-Tuss DM, GG/DM, Mastussin DM, Recofen D, Recofen Plus, Ri-Tussin DM, Robichem DM, T-Tussin DM, Tusscidin DM, Bidex-DMI, Humibid CS, GG-DM SR, Humigen DM, Tussidin DM, Altarussin DM, Guiat Clear DM, Guaiasorb Cough Medicine, Kita La Tos, Q-Tussin DM, Bidex-DM, Nalspan Senior DX, Vicks Formula 44 Custom Care Chesty Cough, Scot-Tussin Senior, Mucinex Fast-Max DM Max, Naldecon DX Liquigel, Safetussin 30 DM, Alka-Seltzer Plus Mucus & Congestion, Pecgen DMX, Duratuss DM, Guiatuss Clear, Allfen DM, S-Pack DM, HT Tuss DM, Monafed DM, Hydro-Tuss DM, Drituss DM, Guaifen DM, Maxi-Tuss DM, Su-Tuss DM, Biospec DMX, Muco-Fen 800 DM, Delsym Children’s Cough+ Chest Congestion DM, Guai-Dex, Guaifenesin DM SR, Tussi-Bid, Sudal DM, Ru-Tuss 800 DM, Mintab DM, Bidex-A, Mindal DM, Robitussin Children' s Cough & Chest Congestion DM, Z-Cof LA, Extuss LA, ExeFen-DM, Siltussin DM DAS Cough Formula, Simuc-DM, DuraDEX, Mucus Relief DM, Relacon LAX, Aquatab DM, Z-Cof LAX, Robafen DM Clear, DuraDEX Forte, Zotex DMX, Tussi-Organidin DM-S NR, Robitussin Cough + Chest Congestion Sugar-Free DM, Guaifen DM NR, Guiadrine DX, Balminil DM + Expectorant Sugar Free, Vicks Nature Fusion Cough & Chest Congestion, G Bid DM, Atuss-12 DX, Cheracol-D, G-Zyncof, Robafen DM Max, Guaibid DM, Robitussin Cough + Chest Congestion DM Maximum Strength, Safetussin DM, Tussin DM Clear, Congesta DM, Mucosa DM, TabTussin DM, Tusnel Diabetic, Siltussin-DM DAS-NA, Siltussin-DM DAS-NA Maximum Strength, Duratuss DM 12, Refenesen Chest Congestion Relief DM, Brontuss, Tussi-Organidin-DM, Coricidin HBP Multi-Symptom Cold (Day), Triaminic Cough & Congestion, Dex-Tuss DM, Fenesin DM IR, Vicks DayQuil Cough & Congestion, Mucus Relief Cough, Gani-Tuss-DM NR, Muco-Fen DM, Guiadrine DM, Fenex-DM, Iobid DM, Q-Bid DM, Touro DM, Respa-DM, Mucobid DM, Fenesin DM, Iofen-DM NF, Phanatuss, Naldecon Senior DX, Halotussin DM, Double-Tussin DM, Halotussin DM Sugar Free, Rhinosyn-DMX, Tuss-DM, Kolephrin GG/DM, Amibid DM, Duraganidin, Genatuss DM, Glycotuss-DM, Mytussin DM, Tolu-Sed DM, Guiacough DM, Lotussin DM, Aquabid DM)
  • Diastat AcuDial (diazepam)
  • Dilaudid (hydromorphone)
  • Flexeril (cyclobenzaprine)
  • Levaquin (levofloxacin)
  • Levaquin Leva-Pak (levofloxacin)
  • Lotrel (amlodipine / benazepril)
  • Lumigan (bimatoprost ophthalmic)
  • Namenda (memantine)
  • Neurontin (gabapentin)
  • Pepto-Bismol (bismuth subsalicylate)
  • Prevacid (lansoprazole)
  • Prilosec (omeprazole)
  • Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)

Dextromethorphan / guaifenesin / pseudoephedrine alcohol/food interactions

There is 1 alcohol/food interaction with dextromethorphan / guaifenesin / pseudoephedrine

Dextromethorphan / guaifenesin / pseudoephedrine disease interactions

There are 7 disease interactions with dextromethorphan / guaifenesin / pseudoephedrine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.