Acetaminophen/codeine/guaifenesin/phenylephrine Drug Interactions
Currently displaying a list of 731 drugs known to interact with acetaminophen / codeine / guaifenesin / phenylephrine.
- 151 major drug interactions
- 569 moderate drug interactions
- 11 minor drug interactions
Medications known to interact with acetaminophen/codeine/guaifenesin/phenylephrine
Note: Showing generic names only.
- abametapir topical
- abiraterone
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acrivastine
- adagrasib
- albiglutide
- albuterol
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alogliptin
- alprazolam
- alvimopan
- amifampridine
- amiloride
- aminophylline
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- anagrelide
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atezolizumab
- atomoxetine
- atropine
- atropine ophthalmic
- attapulgite
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
- baclofen
- baricitinib
- bedaquiline
- belladonna
- belzutifan
- benazepril
- bendroflumethiazide
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- betaxolol ophthalmic
- bexagliflozin
- biperiden
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- bitolterol
- black cohosh
- bosentan
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
- caffeine
- calaspargase pegol
- canagliflozin
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carteolol ophthalmic
- carvedilol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cholestyramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- colchicine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyproheptadine
- dabrafenib
- daclizumab
- dacomitinib
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- deferasirox
- delavirdine
- deserpidine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- difelikefalin
- diflunisal
- digitoxin
- digoxin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dobutamine
- dolasetron
- dopamine
- dostarlimab
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- droxidopa
- dulaglutide
- duloxetine
- durvalumab
- echinacea
- efavirenz
- eletriptan
- eliglustat
- eluxadoline
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- enzalutamide
- ephedrine
- epinephrine
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- ergonovine
- ergotamine
- ertugliflozin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- etravirine
- evening primrose
- exenatide
- ezogabine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- frovatriptan
- furazolidone
- furosemide
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gepirone
- ginkgo
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- goldenseal
- granisetron
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- halazepam
- halofantrine
- haloperidol
- halothane
- heroin
- homatropine ophthalmic
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- indacaterol
- indapamide
- indocyanine green
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iobenguane I 123
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- irbesartan
- isocarboxazid
- isoetharine
- isoflurane
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- levalbuterol
- levamlodipine
- levetiracetam
- levobetaxolol ophthalmic
- levobunolol ophthalmic
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- lindane topical
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lixisenatide
- lofexidine
- lomitapide
- lonapegsomatropin
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- ma huang
- maprotiline
- mavorixafor
- mazindol
- mebrofenin
- mecamylamine
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methysergide maleate
- metipranolol ophthalmic
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metyrosine
- mibefradil
- midazolam
- midodrine
- miglitol
- milnacipran
- minoxidil
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
- nabilone
- nadolol
- nafcillin
- nalbuphine
- naloxone
- naltrexone
- naratriptan
- nateglinide
- nebivolol
- nefazodone
- nevirapine
- nicardipine
- nicotine
- nifedipine
- nilotinib
- nimodipine
- niraparib
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nivolumab
- norepinephrine
- nortriptyline
- olanzapine
- oliceridine
- olmesartan
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- orphenadrine
- osilodrostat
- ospemifene
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
- paliperidone
- palonosetron
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pegvisomant
- pembrolizumab
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- pralsetinib
- pramipexole
- pramlintide
- pramoxine topical
- prasugrel
- prazosin
- pregabalin
- primaquine
- primidone
- probenecid
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pseudoephedrine
- pyrilamine
- racepinephrine
- ramelteon
- ramipril
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- retifanlimab
- rifabutin
- rifampin
- rifapentine
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- safinamide
- salmeterol
- saxagliptin
- scopolamine
- scopolamine ophthalmic
- secobarbital
- selegiline
- selexipag
- semaglutide
- sertraline
- sevoflurane
- sibutramine
- sildenafil
- silodosin
- sitagliptin
- sodium oxybate
- sodium polystyrene sulfonate
- sodium salicylate
- sofpironium topical
- solifenacin
- solriamfetol
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
- tafamidis
- tamsulosin
- tapentadol
- tasimelteon
- tebentafusp
- tedizolid
- telmisartan
- telotristat
- temazepam
- terazosin
- terbinafine
- terbutaline
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- timolol ophthalmic
- tirzepatide
- tislelizumab
- tizanidine
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treprostinil
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- tropicamide ophthalmic
- trospium
- tryptophan
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- varenicline
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vortioxetine
Acetaminophen/codeine/guaifenesin/phenylephrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / codeine / guaifenesin / phenylephrine.
Acetaminophen/codeine/guaifenesin/phenylephrine disease interactions
There are 23 disease interactions with acetaminophen / codeine / guaifenesin / phenylephrine which include:
- alcoholism
- liver disease
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- cardiovascular disease
- PKU
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
- BPH
- diabetes
- glaucoma
More about acetaminophen / codeine / guaifenesin / phenylephrine
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Robitussin Nighttime Cough DM
Robitussin Nighttime Cough DM is used for cough, cough and nasal congestion
Vicks Nyquil Cough
Vicks Nyquil Cough is used for cough, cough and nasal congestion
Dextromethorphan/guaifenesin/phenylephrine
Dextromethorphan/guaifenesin/phenylephrine systemic is used for cough and nasal congestion
Brompheniramine/dextromethorphan/pseudoephedrine
Brompheniramine/dextromethorphan/pseudoephedrine systemic is used for cough and nasal congestion
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.