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Ultra-Technekow V4 Dosage

Generic name: TECHNETIUM TC-99M SODIUM PERTECHNETATE 1Ci
Dosage form: injection, solution

Medically reviewed by Drugs.com. Last updated on Oct 16, 2024.

Sodium Pertechnetate Tc 99m is administered by intravenous injection. When imaging the nasolacrimal drainage system, instill the Sodium Pertechnetate Tc 99m by the use of a device such as a micropipette or similar method which will ensure the accuracy of the dose.

For imaging the urinary bladder and ureters (direct isotopic cystography), the Sodium Pertechnetate Tc 99m is administered by direct instillation aseptically into the bladder via a urethral catheter, following which the catheter is flushed with approximately 200 mL of sterile saline directly into the bladder.

The suggested dose ranges employed for various diagnostic indications in the average ADULT PATIENT (70 kg) are as follows:

Vesico-ureteral imaging: 18.5 to 37 MBq (0.5 to 1 mCi)
Thyroid gland imaging: 37 to 370 MBq (1 to 10 mCi)
Salivary gland imaging: 37 to 185 MBq (1 to 5 mCi)
Nasolacrimal drainage system: Maximum dose of 3.7 MBq (100 µCi)

The recommended dosages in PEDIATRIC PATIENTS are:

Vesico-ureteral imaging: 18.5 to 37 MBq (0.5 to 1 mCi)
Thyroid gland imaging: 2.22 to 2.96 MBq (60 to 80 µCi) per kg body weight

The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. If the solution is discolored, discontinue use of the generator immediately. The solution to be administered as the patient dose should be clear, colorless, and contain no particulate matter.

Radiation Dosimetry

The estimated absorbed radiation doses to an average ADULTand PEDIATRICpatient from an intravenous injection of various doses of Sodium Pertechnetate Tc 99m distributed uniformly in the total body are shown in Tables 5 and 6.

Table 5. Absorbed Radiation Doses from Intravenous Injection

Organ

Absorbed Radiation Dose (mGy) for a 1110 MBq (30mCi) dose

Adrenals

4.1

Urinary Bladder Wall

20

Bone Surfaces

6.2

Brain

2.2

Breasts

2

Gallbladder Wall

8.3

Stomach Wall

29

Small Intestine

18

ULI Wall

63

LLI Wall

23

Heart Wall

3.5

Kidneys

6

Liver

4.7

Lungs

2.9

Muscle

3.6

Ovaries

11

Pancreas

6.3

Red Marrow

4.1

Skin

2

Spleen

4.8

Testes

3.1

Thymus

2.7

Thyroid

24

Uterus

9

Remaining Tissues

3.9

Effective Dose (mSv)

14

To obtain radiation absorbed dose in rads (30 mCi dose) from the above table, divide individual organ values by a factor of 10 (does not apply for effective dose).

Table 6. Pediatric Absorbed Radiation Doses (mGy) from Intravenous Injection

Age

15 years

10 years

5 years

1 year

Administered activityin MBq (mCi)

1110
(30)

740
(20)

555
(15)

370
(10)

Organ

Adrenals

5.3

5.4

6.2

7.1

Urinary Bladder Wall

26

22

18

22

Bone Surfaces

7.6

7.5

8.1

10

Brain

2.8

3.1

3.7

4.5

Breasts

2.6

2.6

3.2

4.1

Gallbladder Wall

11

12

13

13

Stomach Wall

38

36

43

59

Small Intestine

22

23

26

30

ULI Wall

81

89

110

140

LLI Wall

31

33

40

48

Heart Wall

4.5

4.6

5.2

6.4

Kidneys

7.2

6.9

7.8

8.5

Liver

6

6.7

8

9.1

Lungs

3.8

3.8

4.4

5.3

Muscle

4.5

4.5

5

6

Ovaries

14

13

14

17

Pancreas

8.1

8.2

8.9

10

Red Marrow

5.1

5

5.2

6

Skin

2.5

2.6

3.2

3.8

Spleen

6

6

6.7

7.8

Testes

4.1

4.3

4.9

6

Thymus

3.6

3.5

4.2

5.3

Thyroid

40

41

67

81

Uterus

11

11

12

14

Remaining Tissues

4.8

4.8

5.4

6.4

Effective Dose (mSv)

19

19

23

29

To obtain radiation absorbed dose in rads (30 mCi dose) from the above table, divide individual organ values by a factor of 10 (does not apply for effective dose).

The estimated absorbed radiation doses to an ADULT patient from the nasolacrimal imaging procedure using a maximum dose of 3.7 megabecquerels (100 microcuries) of Sodium Pertechnetate Tc 99m are shown in Table 7.

Table 7. Absorbed Radiation Doses from Dacryoscintigraphy

Tissue

3.7 MBq (100 µCi)
Dose of Sodium Pertechnetate Tc 99m

mGy

rad

Eye Lens:

If lacrimal fluid turnover is 16%/min

0.140

0.014

If lacrimal fluid
turnover is 100%/min

0.022

0.002

If drainage
system is blocked

4.020

0.402

Total Body*

0.011

0.001

Ovaries*

0.030

0.003

Testes*

0.009

0.001

Thyroid*

0.130

0.013

*Assuming no blockage of draining system.

In pediatric patients, an average 30 minute exposure to 37 MBq (1 mCi) of Tc-99m pertechnetate following instillation for direct cystography, will result in the following estimated radiation doses:

Table 8. Absorbed Radiation Doses from Cystography (PEDIATRIC)

Age

Bladder wall dose, mGy (rad)

Gonadal dose,
mGy (rad)

1 year

3.6 (0.36)

0.15 (0.015)

5 years

2.0 (0.2)

0.095 (0.0095)

10 years

1.3 (0.13)

0.066 (0.0066)

15 years

0.92 (0.092)

0.046 (0.0046)

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