Ultra-Technekow V4 Dosage
Generic name: TECHNETIUM TC-99M SODIUM PERTECHNETATE 1Ci
Dosage form: injection, solution
Medically reviewed by Drugs.com. Last updated on Oct 16, 2024.
Sodium Pertechnetate Tc 99m is administered by intravenous injection. When imaging the nasolacrimal drainage system, instill the Sodium Pertechnetate Tc 99m by the use of a device such as a micropipette or similar method which will ensure the accuracy of the dose.
For imaging the urinary bladder and ureters (direct isotopic cystography), the Sodium Pertechnetate Tc 99m is administered by direct instillation aseptically into the bladder via a urethral catheter, following which the catheter is flushed with approximately 200 mL of sterile saline directly into the bladder.
The suggested dose ranges employed for various diagnostic indications in the average ADULT PATIENT (70 kg) are as follows:
Vesico-ureteral imaging: 18.5 to 37 MBq (0.5 to 1 mCi)
Thyroid gland imaging: 37 to 370 MBq (1 to 10 mCi)
Salivary gland imaging: 37 to 185 MBq (1 to 5 mCi)
Nasolacrimal drainage system: Maximum dose of 3.7 MBq (100 µCi)
The recommended dosages in PEDIATRIC PATIENTS are:
Vesico-ureteral imaging: 18.5 to 37 MBq (0.5 to 1 mCi)
Thyroid gland imaging: 2.22 to 2.96 MBq (60 to 80 µCi) per kg body weight
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. If the solution is discolored, discontinue use of the generator immediately. The solution to be administered as the patient dose should be clear, colorless, and contain no particulate matter.
Radiation Dosimetry
The estimated absorbed radiation doses to an average ADULTand PEDIATRICpatient from an intravenous injection of various doses of Sodium Pertechnetate Tc 99m distributed uniformly in the total body are shown in Tables 5 and 6.
Table 5. Absorbed Radiation Doses from Intravenous Injection
Organ |
Absorbed Radiation Dose (mGy) for a 1110 MBq (30mCi) dose |
Adrenals |
4.1 |
Urinary Bladder Wall |
20 |
Bone Surfaces |
6.2 |
Brain |
2.2 |
Breasts |
2 |
Gallbladder Wall |
8.3 |
Stomach Wall |
29 |
Small Intestine |
18 |
ULI Wall |
63 |
LLI Wall |
23 |
Heart Wall |
3.5 |
Kidneys |
6 |
Liver |
4.7 |
Lungs |
2.9 |
Muscle |
3.6 |
Ovaries |
11 |
Pancreas |
6.3 |
Red Marrow |
4.1 |
Skin |
2 |
Spleen |
4.8 |
Testes |
3.1 |
Thymus |
2.7 |
Thyroid |
24 |
Uterus |
9 |
Remaining Tissues |
3.9 |
Effective Dose (mSv) |
14 |
To obtain radiation absorbed dose in rads (30 mCi dose) from the above table, divide individual organ values by a factor of 10 (does not apply for effective dose).
Table 6. Pediatric Absorbed Radiation Doses (mGy) from Intravenous Injection
Age |
15 years |
10 years |
5 years |
1 year |
Administered activityin MBq (mCi) |
1110 |
740 |
555 |
370 |
Organ |
||||
Adrenals |
5.3 |
5.4 |
6.2 |
7.1 |
Urinary Bladder Wall |
26 |
22 |
18 |
22 |
Bone Surfaces |
7.6 |
7.5 |
8.1 |
10 |
Brain |
2.8 |
3.1 |
3.7 |
4.5 |
Breasts |
2.6 |
2.6 |
3.2 |
4.1 |
Gallbladder Wall |
11 |
12 |
13 |
13 |
Stomach Wall |
38 |
36 |
43 |
59 |
Small Intestine |
22 |
23 |
26 |
30 |
ULI Wall |
81 |
89 |
110 |
140 |
LLI Wall |
31 |
33 |
40 |
48 |
Heart Wall |
4.5 |
4.6 |
5.2 |
6.4 |
Kidneys |
7.2 |
6.9 |
7.8 |
8.5 |
Liver |
6 |
6.7 |
8 |
9.1 |
Lungs |
3.8 |
3.8 |
4.4 |
5.3 |
Muscle |
4.5 |
4.5 |
5 |
6 |
Ovaries |
14 |
13 |
14 |
17 |
Pancreas |
8.1 |
8.2 |
8.9 |
10 |
Red Marrow |
5.1 |
5 |
5.2 |
6 |
Skin |
2.5 |
2.6 |
3.2 |
3.8 |
Spleen |
6 |
6 |
6.7 |
7.8 |
Testes |
4.1 |
4.3 |
4.9 |
6 |
Thymus |
3.6 |
3.5 |
4.2 |
5.3 |
Thyroid |
40 |
41 |
67 |
81 |
Uterus |
11 |
11 |
12 |
14 |
Remaining Tissues |
4.8 |
4.8 |
5.4 |
6.4 |
Effective Dose (mSv) |
19 |
19 |
23 |
29 |
To obtain radiation absorbed dose in rads (30 mCi dose) from the above table, divide individual organ values by a factor of 10 (does not apply for effective dose).
The estimated absorbed radiation doses to an ADULT patient from the nasolacrimal imaging procedure using a maximum dose of 3.7 megabecquerels (100 microcuries) of Sodium Pertechnetate Tc 99m are shown in Table 7.
Table 7. Absorbed Radiation Doses from Dacryoscintigraphy
Tissue |
3.7 MBq (100 µCi) |
|
mGy |
rad |
|
Eye Lens: If lacrimal fluid turnover is 16%/min |
0.140 |
0.014 |
If lacrimal fluid |
0.022 |
0.002 |
If drainage |
4.020 |
0.402 |
Total Body* |
0.011 |
0.001 |
Ovaries* |
0.030 |
0.003 |
Testes* |
0.009 |
0.001 |
Thyroid* |
0.130 |
0.013 |
*Assuming no blockage of draining system.
In pediatric patients, an average 30 minute exposure to 37 MBq (1 mCi) of Tc-99m pertechnetate following instillation for direct cystography, will result in the following estimated radiation doses:
Table 8. Absorbed Radiation Doses from Cystography (PEDIATRIC)
Age |
Bladder wall dose, mGy (rad) |
Gonadal dose, |
1 year |
3.6 (0.36) |
0.15 (0.015) |
5 years |
2.0 (0.2) |
0.095 (0.0095) |
10 years |
1.3 (0.13) |
0.066 (0.0066) |
15 years |
0.92 (0.092) |
0.046 (0.0046) |
More about Ultra-Technekow V4 (sodium pertechnetate (tc-99m))
Professional resources
Other brands
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.