Rezipres Dosage
Generic name: EPHEDRINE HYDROCHLORIDE 47mg in 10mL
Dosage form: injection, solution
Drug class: Vasopressors
Medically reviewed by Drugs.com. Last updated on Dec 4, 2023.
2.1 General Dosage and Administration Instructions
REZIPRES® 47 mg/mL must be diluted before administration as an intravenous bolus to achieve the desired concentration. Dilute with 0.9% Sodium Chloride Injection or 5% Dextrose Injection
REZIPRES® 9.4 mg/mL can be either used as provided at 9.4 mg/mL or it can be diluted, with 5% Dextrose Injection or 0.9% Sodium Chloride Injection, to achieve the desired concentration, before administration as an intravenous bolus.
If the Rezipres diluted solution is not used immediately, store at controlled room temperature at 20°C to 25°C (68°F to 77°F) for up to 4 hours or refrigerate at 2°C to 8°C (36°F to 46°F) for no more than 24 hours. Discard the unused Rezipres diluted solution after 4 hours if stored at controlled room temperature or after 24 hours if refrigerated.
REZIPRES® 4.7 mg/mL is a premixed formulation. Do not dilute prior to use.
- REZIPRES® is a clear, colorless solution. Discard any unused portion.
- Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if the solution is not clear or if particulate matter is present.
2.2 Dosing for Treatment of Clinically Important Hypotension in the Setting of Anesthesia
The recommended dosages for the treatment of clinically important hypotension in the setting of anesthesia is an initial dose of 4.7 mg to 9.4 mg administered by intravenous bolus. Administer additional boluses as needed, not to exceed a total dosage of 47 mg.
- Adjust dosage according to the blood pressure goal (i.e., titrate to effect).
2.3 Prepare a 4.7 mg/mL Solution for Bolus Intravenous Administration
REZIPRES® 47 mg/mL
- Withdraw 47 mg (1 mL of 47 mg/mL) of REZIPRES® 47 mg/mL and dilute with 9 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection.
- Withdraw an appropriate dose of the 4.7 mg/mL solution prior to bolus intravenous administration.
REZIPRES® 9.4 mg/mL
- Withdraw 5 mL of REZIPRES® 9.4 mg/mL and dilute with 5 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection.
- Withdraw an appropriate dose of the 4.7 mg/mL solution prior to bolus intravenous administration.
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