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Nirmatrelvir / Ritonavir Dosage

Medically reviewed by Drugs.com. Last updated on Mar 19, 2024.

Applies to the following strengths: 150 mg-100 mg (300 mg-100 mg Dose); 150 mg-100 mg (150 mg-100 mg Dose)

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for COVID-19

Nirmatrelvir: 300 mg orally twice a day
Ritonavir: 100 mg orally twice a day

Duration of therapy: 5 days

Comments:


Use: For the treatment of mild to moderate COVID-19 in patients who are at high risk for progression to severe COVID-19, including hospitalization or death

Usual Pediatric Dose for COVID-19

For investigational use only

12 years and older, weighing at least 40 kg:


Duration of therapy: 5 days

Comments:

Use: For the treatment of patients with mild to moderate COVID-19 and who are at high risk for progression to severe COVID-19, including hospitalization or death

Renal Dose Adjustments

Mild renal dysfunction (estimated GFR [eGFR] 60 to less than 90 mL/min): No adjustment recommended

Moderate renal dysfunction (eGFR 30 to less than 60 mL/min):

Duration of therapy: 5 days

Severe renal dysfunction (eGFR less than 30 mL/min): Not recommended

Comments:

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended
Severe liver dysfunction (Child-Pugh C): Not recommended

Comments:

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years; this product is not authorized for use in pediatric patients weighing less than 40 kg or younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD (eGFR less than 15 mL/min) receiving dialysis: Not recommended

Other Comments

Administration advice:


Storage requirements:

General:
For EUA:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.