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Methotrimeprazine Dosage

Applies to the following strengths: 20 mg/mL

Usual Adult Dose for Anxiety

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Depression

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Mania

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Psychosis

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Trigeminal Neuralgia

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Schizophrenia

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Nausea/Vomiting

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Neuropathic Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Breakthrough Pain

ORAL:
Minor conditions (e.g., as an analgesic, anxiolytic, sedative, tranquilizer): 6 to 25 mg orally per day, given in 3 divided doses
Severe conditions (e.g., for psychoses or intense pain):
-Initial dose: 50 to 75 mg orally per day, given in divided doses 2 to 3 times per day
-Maximum dose: 1000 mg/day

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day
-Adjunct to post-operative analgesic: 10 to 25 mg via IM injection every 8 hours

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Patients requiring initial oral doses of 100 to 200 mg/day should be given the drug in divided doses and should be kept in bed for the first few days.

Uses:
-As an adjunct to post-operative analgesia
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomfort
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Treatment of acute schizophrenia
-Treatment of chronic schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Adult Dose for Insomnia

ORAL:
-Initial dose: 6 to 25 mg orally per day, given in 3 divided doses with meals
-Sedative: 10 to 25 mg orally once a day at night

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:
-Doses should be determined by the condition and the patient's response.
-Initial doses should be increased until an optimal level is achieved.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-Management of insomnia

Usual Adult Dose for Sedation

ORAL:
-Initial dose: 6 to 25 mg orally per day, given in 3 divided doses with meals
-Sedative: 10 to 25 mg orally once a day at night

PARENTERAL:
Injection: 25 mg via IM injection 3 to 4 times a day

Comments:
-Doses should be determined by the condition and the patient's response.
-Initial doses should be increased until an optimal level is achieved.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-Management of insomnia

Usual Pediatric Dose for Anxiety

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Depression

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Insomnia

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Mania

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Pain

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Psychosis

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Sedation

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Trigeminal Neuralgia

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Schizophrenia

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Nausea/Vomiting

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Neuropathic Pain

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Usual Pediatric Dose for Breakthrough Pain

ORAL:
Children:
-Initial dose: 0.25 mg/kg orally per day, given in 2 to 3 divided doses
-Maximum dose: 40 mg/day (in children less than 12 years)

PARENTERAL:
Children:
IM: 0.0625 to 0.125 mg/kg via IM injection once a day or in divided doses

IV: 0.0625 mg/kg via slow IV infusion, at a rate of 20 to 40 drops per minute

Comments:
-Use of this drug with regional or spinal anesthesia is contraindicated.
-IM injections should be administered deep into a large muscle.
-IV formulations should be administered in the context of palliative care.
-Doses given concurrently with narcotics should be appropriately reduced.
-Doses should be determined by the condition and the patient's response.
-If patients experience daytime sedation, a larger portion of the dose may be given in the evening.
-Oral formulations should be substituted for parenteral formulations as soon as possible.
-Initial doses should be increased until an optimal level is achieved.

Uses:
-As a potentiator of anesthetics in general anesthesia for pre- and post-operative sedation and analgesia
-As an adjunct to post-operative analgesia
-As an analgesic in muscular discomforts
-As an analgesic in pain due to cancer
-As an analgesic in pain due to muscular discomforts
-As an analgesic in pain due to neurocostal neuralgia
-As an analgesic in pain due to trigeminal neuralgia
-As an analgesic in pain due to zona
-As an analgesic in phantom limb pains
-Management of insomnia
-Treatment of acute schizophrenia
-Treatment of conditions associated with anxiety and tension (e.g., autonomic disturbances, emotional disturbances secondary to resistant pruritus and other physical conditions, personality disturbances)
-Treatment of chronic schizophrenia
-Treatment of manic-depressive syndromes
-Treatment of nausea and vomiting of central origin
-Treatment of psychotic disturbances
-Treatment of senile psychoses

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Contraindicated

Dose Adjustments

Patients with arteriosclerosis or cardiovascular disorders: Patients should begin with low initial treatment doses.

Large initial oral doses: Patients should be kept in bed for the first few days.

Patients taking other phenothiazines and/or central nervous system (CNS) depressants concomitantly: The usual dose of these agent(s) should be decreased by 50% if they are taken concomitantly until the dose of this drug is established.

Parenteral doses for adjunctive post-operative analgesia of 10 to 25 mg every 8 hours are equivalent to 20 to 40 mg oral doses.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-In patients with blood dyscrasias
-Liver dysfunction
-Patients with brain damage
-Patients with central nervous system (CNS) depression or coma due to alcohol, analgesics, hypnotics, or narcotics
-Patients with circulatory collapse, severe heart disorder, and/or severe hypotension
-Pheochromocytoma
-Regional or spinal anesthesia
-Sensitivity to phenothiazines

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Continuous subcutaneous infusions should be given with a syringe driver.
-Injections may be given via IM or IV.

Storage requirements:
-Protect from light

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.

IV compatibility:
-Compatible: Normal saline, diamorphine

General:
-Limitation of use: This drug should not be used to treat dementia-related behavioral disturbances.
-This drug does not significantly decrease respiration, and may be useful in patients with low pulmonary reserve.

Monitoring:
-CARDIOVASCULAR: ECG should be considered prior to starting treatment, before dose escalations, and in patients at maximum therapeutic doses
-HEMATOLOGIC: Complete blood count (CBC) testing prior to staring treatment, regularly during the first 2 to 3 months after initiation, and periodically thereafter
-HEPATIC: Liver function tests should be performed periodically (e.g., at least every 6 to 12 months) in patients receiving long-term treatment
-METABOLIC: Glycemic monitoring, especially during initiation; weight monitored regularly during treatment; serum electrolyte levels periodically during chronic treatment

Patient advice:
-Inform patients that this drug may cause confusion, disorientation, drowsiness, and/or excessive hypotension, and they should avoid driving or operating machinery if these side effects occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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