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Isuprel Dosage

Medically reviewed by Drugs.com. Last updated on Aug 3, 2020.

Generic name: ISOPROTERENOL HYDROCHLORIDE 0.2mg in 1mL
Dosage form: injection, solution

Recommended Dosage

Start ISUPREL injection at the lowest recommended dose and increase the rate of administration gradually if necessary while carefully monitoring the patient. The usual route of administration is by intravenous infusion or bolus intravenous injection. In dire emergencies, the drug may be administered by intracardiac injection. If time is not of the utmost importance, initial therapy by intramuscular or subcutaneous injection is preferred.

Recommended dosage for adults with heart block, Adams-Stokes attacks, and cardiac arrest:

Route of

Administration

Preparation of Dilution

Initial
Dose

Subsequent

Dose Range

Bolus intravenous injection

Dilute 1 mL (0.2 mg) in 9 mL of Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP

0.02 mg to 0.06 mg

(1 mL to 3 mL of diluted solution)

0.01 mg to 0.2 mg

(0.5 mL to 10 mL of diluted solution)

Intravenous infusion

Dilute 10 mL (2 mg) in 500 mL of 5% Dextrose Injection, USP

5 mcg/min. (1.25 mL of diluted solution per minute)

Intramuscular

Use Solution undiluted

0.2 mg (1 mL)

0.02 mg to 1 mg

(0.1 mL to 5 mL)

Subcutaneous

Use Solution undiluted

0.2 mg (1 mL)

0.15 mg to 0.2 mg

(0.75 mL to 1 mL)

Intracardiac

Use Solution undiluted

0.02 mg (0.1 mL)

There are no well-controlled studies in children to establish appropriate dosing; however, the American Heart Association recommends an initial infusion rate of 0.1 mcg/kg/min, with the usual range being 0.1 mcg/kg/min to 1 mcg/kg/min.

Recommended dosage for adults with shock and hypoperfusion states:

Route of Administration

Preparation of Dilution

Infusion Rate

Intravenous infusion

Dilute 5 mL (1 mg) in 500 mL of 5% Dextrose Injection, USP

0.5 mcg to 5 mcg per minute (0.25 mL to 2.5 mL of diluted solution)

Recommended dosage for adults with bronchospasm occurring during anesthesia:

Route of Administration

Preparation of Dilution

Initial Dose

Subsequent Dose

Bolus intravenous injection

Dilute 1 mL (0.2 mg) in 9 mL of Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP

0.01 mg to 0.02 mg
(0.5 mL to 1 mL of diluted solution)

The initial dose may be repeated when necessary

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Such solution should not be used.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.