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Isoproterenol Hydrochloride


Class: Non-selective beta-Adrenergic Agonists
VA Class: AU100
CAS Number: 51-30-9


Sympathomimetic agent that acts directly on both β1- and β2-adrenergic receptors (nonselective β-agonist).a

Uses for Isoproterenol Hydrochloride

Cardiac Arrhythmias and Cardiac Arrest

Used for treatment of heart block and Adams-Stokes attacks.140 170 Also has been used for treatment of ventricular arrhythmias secondary to AV nodal block and carotid sinus hypersensitivity.a However, evidence supporting benefit in patients with cardiac arrhythmias generally lacking; safer and more effective alternatives such as cardiac pacing and other drug therapies are available.170

Has been used in the treatment of cardiac arrest until defibrillation or emergency pacemaker therapy could be employed.a However, experts state that isoproterenol is not a drug of choice in ACLS and should only be considered in this setting for treatment of symptomatic bradycardia unresponsive to atropine or as a temporary measure until pacemaker therapy can be instituted.133 170 401 Should not be used for resuscitation in patients with cardiac arrest or hypotension because of potential deleterious effects (e.g., exacerbation of ischemia, arrhythmias, peripheral vasodilation).a

Must not be administered to patients with acetylcholinesterase-induced bradycardias; however, may be beneficial at high doses in refractory bradycardia caused by β-adrenergic blocking agents.136


Used as adjunctive therapy to produce cardiac stimulation and vasodilation in the treatment of shock.a

The value of isoproterenol therapy in shock has been questioned because the drug increases oxygen demand in the myocardium and other tissues to levels that may not be met by increased blood flow.a Efficacy in reducing mortality in refractory shock not demonstrated.a

Vasopressors such as norepinephrine and epinephrine generally considered drugs of choice for effective hemodynamic management of shock.153

Isoproterenol generally not recommended for cardiogenic shock; increases in myocardial oxygen consumption and cardiac workload usually outweigh benefits, and arrhythmias can occur more readily.a

Should not be used in patients with drug-induced distributive shock; may worsen hypotension by further decreasing systemic vascular resistance.136


IV isoproterenol may be useful in bronchospasm occurring during anesthesia but must be administered with extreme caution, if at all, in patients receiving cyclopropane or halogenated hydrocarbon general anesthetics.a

Has been used as a bronchodilator in the symptomatic treatment of bronchial asthma and reversible bronchospasm that may occur in association with chronic bronchitis, pulmonary emphysema, bronchiectasis, and other chronic obstructive pulmonary disorders.a However, oral, sublingual, and oral inhalation preparations of the drug no longer are commercially available in the US.a

Pulmonary Embolism

Has been used by IV infusion to reverse decreases in cardiac output and circulating pulmonary blood volume and to reverse increases in pulmonary arterial pressure and pulmonary vascular resistance occurring during pulmonary embolism.a

Diagnosis of CAD and Other Cardiac Abnormalities

Has been used as an aid in the diagnosis of CAD.a Also has been used in the diagnosis of CAD by increasing myocardial oxygen consumption and intensifying symptoms of ischemia.a

Has been used as an aid in diagnosing the etiology of mitral regurgitation.a

Isoproterenol Hydrochloride Dosage and Administration


  • Select dosage and method of administration according to patient response and specific clinical situation.140

  • Initiate therapy at lowest recommended dose and increase gradually, if necessary, while monitoring the patient.140

  • Adjust dosage according to clinical and hemodynamic parameters including heart rate, central venous pressure, systemic BP, and urine output.140


Usually administer IV.140

May administer by intracardiac injection in extreme emergencies (in adults).140 In less urgent situations, initial IM or sub-Q injection is preferred.140

Dilute commercially available isoproterenol hydrochloride injection prior to IV administration.140 For IM, sub-Q, or intracardiac injection, administer injection solution undiluted.140

IV Administration

For solution and drug compatibility information, see Compatibility under Stability.

Administer by direct (“bolus”) IV injection or IV infusion.140


To prepare diluted solution for direct IV injection, add 1 mL of the injection containing isoproterenol hydrochloride 0.2 mg/mL to 9 mL of 0.9% sodium chloride injection or 5% dextrose injection.140

To prepare diluted solution for IV infusion, add 10 mL of the injection containing isoproterenol hydrochloride 0.2 mg/mL to 500 mL of 5% dextrose injection.140

Rate of Administration

When the drug is administered by IV infusion, especially as an adjunct in the treatment of shock, adjust rate of infusion based on patient’s heart rate, central venous pressure, systemic BP, and urine flow.a

If heart rate >110 beats/minute or if premature heart beats or changes in ECG develop, consider slowing rate of infusion or temporarily discontinuing the infusion.a


Available as isoproterenol hydrochloride; dosage expressed in terms of the salt.140

Pediatric Patients

Cardiac Arrhythmias and Cardiac Arrest

No well-controlled studies have been conducted in pediatric patients to inform dosing; however, AHA recommends initial rate of 0.1 mcg/kg per minute in children and subsequent rate generally ranging from 0.1–1 mcg/kg per minute.140

For the management of complete heart block following closure of ventricular septal defects, IV doses of 0.01–0.03 mg have been administered in infants.a


Cardiac Arrhythmias and Cardiac Arrest

Although manufacturer makes dosage recommendations for patients with cardiac arrest, most experts state that isoproterenol should not be used for cardiopulmonary resuscitation.a (See Cardiac Arrhythmias and Cardiac Arrest under Uses.)

IV Infusion

Manufacturer recommends initial dosage of 5 mcg/minute (1.25 mL of the diluted solution per minute) for treatment of heart block, Adams-Stokes attacks, or cardiac arrest; adjust subsequent dosage based on patient response (generally ranges from 2–20 mcg/minute).a

For treatment of symptomatic bradycardia unresponsive to atropine during ACLS, recommended dosage is 2–10 mcg/minute; adjust infusion rate according to heart rate and rhythm response.

IV injection

Manufacturer recommends initial dose of 0.02–0.06 mg (1–3 mL of the diluted solution) for treatment of heart block, Adams-Stokes attacks, or cardiac arrest; subsequent doses range from 0.01–0.2 mg (0.5–10 mL of the diluted solution).140

For the management of complete heart block following closure of ventricular septal defects, IV doses of 0.04–0.06 mg have been used in adults.a


Manufacturer recommends initial dose of 0.2 mg (1 mL of the commercially available 0.2-mg/mL injection without dilution) for treatment of heart block, Adams-Stokes attacks, or cardiac arrest; subsequent doses range from 0.02–1 mg.140


Manufacturer recommends initial dose of 0.2 mg (1 mL of the commercially available 0.2-mg/mL injection without dilution) for treatment of heart block, Adams-Stokes attacks, or cardiac arrest; subsequent doses range from 0.15–0.2 mg.140

IV Infusion

Manufacturer suggests 0.5–5 mcg (0.25–2.5 mL of the diluted solution) per minute.140 In advanced stages of shock, rates >30 mcg/minute have been used.140

IV injection

Manufacturer recommends initial dose of 0.01–0.02 mg (0.5–1 mL of the diluted solution); dose may be repeated if necessary.140


Has been administered in IV doses of 0.01–0.02 mg, repeated as needed.a

Diagnosis of CAD and Other Cardiac Abnormalities
IV Infusion

Has been administered by IV infusion at a rate of 1–3 mcg/minute in the diagnosis of CAD or lesions or at a rate of 4 mcg/minute as an aid in diagnosing the etiology of mitral regurgitation.a

Special Populations

Renal Impairment

No specific dosage recommendations.140 Administer with caution.140

Geriatric Patients

Careful dosage selection recommended due to possible age-related decrease in hepatic, renal, and/or cardiac function and concomitant disease and drug therapy; initiate therapy at low end of dosage range.140

Cautions for Isoproterenol Hydrochloride


  • Angina pectoris.140

  • Preexisting cardiac arrhythmias (particularly ventricular arrhythmias requiring inotropic therapy and tachyarrhythmias).140

  • Tachycardia or heart block caused by cardiac glycoside intoxication.140



Cardiovascular Effects

In patients with acute MI, isoproterenol may increase the extent of ischemic injury to the myocardium.a Use of the drug as initial agent in the treatment of cardiogenic shock following MI is discouraged.a May cause focal necrosis of myocardial cells.a

Paradoxically, the drug may precipitate Adams-Stokes seizures in some patients with normal sinus rhythm or transient AV block.a It has been suggested that these patients may have had organic disease of the AV node or its branches.a

Evidence of transient myocardial ischemia (i.e., ECG changes and elevation of the cardiac [MB] fraction of creatine kinase [CK, creatine phosphokinase, CPK]) or myocardial dysfunction (i.e., abnormal ECG findings) has been reported with the use of isoproterenol IV infusion for the treatment of severe asthma exacerbation in children.a In patients with asthma receiving isoproterenol infusion, administer oxygen concomitantly; monitor heart rate, BP, and arterial blood gases (maintaining arterial oxygen pressure [PaO2 ] >60 mm Hg); and monitor ECG. Confirm ECG changes suggestive of myocardial ischemia by determining the MB fraction of CK.a

Disturbances of cardiac rhythm and rate produced by isoproterenol may result in palpitation and VT.a Isoproterenol can cause potentially fatal ventricular arrhythmias in doses sufficient to increase heart rate above 130 beats/minute.a

Administration of isoproterenol to patients who are in shock is not a substitute for replacement of blood, plasma, fluids, and/or electrolytes.a

Blood volume depletion must be corrected as fully as possible before the drug is administered.a

Use with caution in patients with CAD, coronary insufficiency, diabetes, hyperthyroidism, and sensitivity to sympathomimetic amines.a

Sensitivity Reactions

Sulfite Sensitivity

Some formulations contain sulfites, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals.140

General Precautions


Pressor therapy is not a substitute for replacement of blood, plasma, fluids, and/or electrolytes.a Correct blood volume depletion as fully as possible before isoproterenol therapy is instituted.a

Additional volume replacement also may be required during administration of isoproterenol; fluid administration must be adequate to compensate for isoproterenol-induced vasodilation, or shock may be worsened.a

Detecting and treating hypovolemia: Monitor central venous pressure or left ventricular filling pressure; in addition, monitor central venous or pulmonary arterial diastolic pressure to avoid overloading the cardiovascular system, diluting serum electrolyte concentrations, and precipitating CHF.a


Monitor ECG, BP, heart rate, urine flow, central venous pressure, blood pH, and blood PCO2 or bicarbonate concentrations.a (See Hypoxia, Hypercapnia, Acidosis, Electrolyte Disturbances under Cautions.) Measure cardiac output and circulation time to determine the patient’s condition and response to therapy.a Ensure adequate ventilation.a Carefully monitor patients who are in shock.a Consider the possibility that isoproterenol may not produce improved capillary perfusion and oxygen delivery while increasing oxygen demand in the myocardium.a

Hypoxia, Hypercapnia, Acidosis, and Electrolyte Disturbances

Must be identified and corrected prior to or during administration of the drug.a May reduce the efficacy and/or increase the incidence of adverse effects of isoproterenol.a

Disease States

Use with caution in geriatric patients, diabetics, patients with renal or cardiovascular disease (including hypertension, CAD, coronary insufficiency, or degenerative heart disease), hyperthyroidism, and/or those with a history of sensitivity to sympathomimetic amines.140

Specific Populations


Category C.140


Not known whether isoproterenol is distributed into human milk.140 Caution advised.140

Pediatric Use

Safety and efficacy not established.140 Has been used in children for certain conditions (e.g., refractory asthma, bradycardia).132 136 137 140

IV infusions of 0.05–2.7 mcg/kg per minute in pediatric patients with refractory asthma have caused clinical deterioration, myocardial necrosis, CHF, and death;140 the risk may be increased by acidosis, hypoxia, and/or concomitant use of other agents (e.g., xanthine derivatives, corticosteroids [see Specific Drugs under Interactions]) likely to be used in these children. If used in pediatric patients with refractory asthma, monitor vital signs continuously and ECG frequently, and determine cardiac-specific (MB) fraction of serum CK (CPK) daily.140

Geriatric Use

Insufficient experience in patients >65 years of age to determine whether geriatric patients respond differently to isoproterenol hydrochloride than younger patients.140 Geriatric healthy individuals or hypertensive patients may be less responsive to β-adrenergic stimulation than younger adults.140 Use with caution because of age-related decreases in hepatic, renal, and/or cardiac function and potential for concomitant disease and drug therapy.140 (See Geriatric Patients under Dosage and Administration.)

Renal Impairment

Use with caution.a

Common Adverse Effects

Nervousness, headache, dizziness, restlessness, insomnia, anxiety, tension, blurring of vision, fear, excitement, tachycardia, palpitations, angina, Adam-Stokes syndrome, pulmonary edema, hypertension, hypotension, ventricular arrhythmias, tachyarrhythmias, flushing of the skin, diaphoresis, mild tremors, weakness.132 135

Interactions for Isoproterenol Hydrochloride

Specific Drugs




Anesthetics, general (e.g., halogenated hydrocarbons [halothane], cyclopropane)

Potential for arrhythmiasa

Use with caution, if at alla

β-Adrenergic blocking agents

Cardiac effects of isoproterenol are antagonizeda

Sympathomimetic agents (e.g., epinephrine)

Additive effects and increased cardiotoxicitya

Do not administer concomitantly; may use alternately with appropriate intervals between dosesa

Xanthine derivatives (e.g., aminophylline, theophylline)

Potential increased or additive cardiotoxic effects; fatal myocardial necrosis has been reported100 101 102 103 132 135

Isoproterenol Hydrochloride Pharmacokinetics



Readily absorbed following parenteral administration.132


Effects persist for few minutes after IV administration.a



Not known whether distributed into human milk.132



Metabolized in the GI tract, liver, lungs, and other tissues.

Elimination Route

Following IV administration, excreted in urine (40–50%) as unchanged drug and remainder as metabolite.a







For information on systemic interactions resulting from concomitant use, see Interactions.


Solution CompatibilityHID 140


Amino acids 4.25%, dextrose 25%

Dextrose 5% in water

Sodium chloride 0.9%

Drug Compatibility
Admixture CompatibilityHID


Atracurium besylate

Calcium chloride

Dobutamine HCl

Floxacillin sodium

Heparin sodium

Magnesium sulfate


Potassium chloride

Ranitidine HCl

Succinylcholine chloride

Verapamil HCl




Sodium bicarbonate

Y-Site CompatibilityHID


Amiodarone HCl

Atracurium besylate


Cisatracurium besylate

Dexmedetomidine HCl


Fenoldopam mesylate

Heparin sodium

Hetastarch in lactated electrolyte injection (Hextend)

Hydrocortisone sodium succinate


Milrinone lactate

Pancuronium bromide

Potassium chloride


Remifentanil HCl

Sodium nitroprusside


Vecuronium bromide


  • Nonselective β-adrenergic agonist.a Little or no effect on α-adrenergic receptors.a

  • Cardiac output usually is increased and may be accompanied by an increase in stroke volume.a

  • Increases myocardial oxygen consumption and the work of the heart and decreases cardiac efficiency.a

  • Lowers peripheral vascular resistance, mainly in skeletal muscle and also in renal and mesenteric vascular beds.140

  • Decreases diastolic BP by producing vasodilation.a Mean BP usually is decreased slightly but may remain unchanged or may be increased slightly if the vasculature already is maximally dilated.a

  • Renal blood flow usually is decreased in normotensive patients, but is substantially increased in patients with shock.140

  • In patients with AV block, isoproterenol shortens conduction time and the refractory period of the AV node and increases the rate and strength of ventricular contraction.a

Advice to Patients

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.140

  • Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.140

  • Importance of informing patients of other important precautionary information. (See Cautions.)140


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Isoproterenol Hydrochloride


Dosage Forms


Brand Names




0.2 mg/mL*

Isoproterenol Hydrochloride Injection

AHFS DI Essentials. © Copyright, 2016, American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

Date modified: July 06, 2016
Last reviewed: June 29, 2016
Date published: July 01, 2005


Only references cited for selected revisions after 1984 are available electronically.

100. Joseph X, Whitehurst VE, Bloom S et al. Enhancement of cardiotoxic effects of beta-adrenergic bronchodilators by aminophylline in experimental animals. Fundam Appl Toxicol. 1981; 1:443-7. [PubMed 6136445]

101. Anon. Interaction between methyl xanthines and beta adrenergic agonists. FDA Drug Bull. 1981; 11:19-20. [PubMed 6119269]

102. Kelly HW. Controversies in asthma therapy with theophylline and the β2-adrenergic agonists. Clin Pharm. 1984; 3:386-95. [IDIS 187701] [PubMed 6147224]

103. Walker SB, Kradjan WA, Bierman CW. Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985; 5:127-37. [IDIS 393481] [PubMed 3895171]

104. Meyer JM, Wenzel CL, Kradjan WA. Salmeterol: a novel, long-acting beta 2-agonist. Ann Pharmacother. 1993; 27:1478-87. [IDIS 323106] [PubMed 7905757]

105. Brogden RN, Faulds D. Salmeterol xinafoate: a review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease. Drugs. 1991; 42:895-912. [PubMed 1723379]

106. Kelly HW. Issues and advances in the pharmacotherapy of asthma. J Clin Pharm Ther. 1992; 17:271-81. [IDIS 304352] [PubMed 1361192]

107. Lipworth BJ. Risks versus benefits of inhaled β2-agonists in the management of asthma. Drug Safety. 1992; 7:54-70. [PubMed 1346963]

108. Sears MR, Taylor DR, Print CG et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet. 1990; 336:1391-6. [IDIS 275192] [PubMed 1978871]

109. Anon. Warnings from the CSM. Int Pharm J. 1991; 5:247-8.

110. Spitzer WO, Sussa S, Ernst P et al. The use of β-agonists and the risk of death and near death from asthma. N Engl J Med. 1992; 326:501-6. [IDIS 291894] [PubMed 1346340]

111. Palmer JBD, Jenkins MM. β2-agonists in asthma. Lancet. 1991; 337:43. [IDIS 275815] [PubMed 1670660]

112. Dahl R. β2-agonists in asthma. Lancet. 1991; 337:43. [IDIS 275815] [PubMed 1670660]

113. Löfdahl CG, Svedmyr N. Beta agonists—friends or foes? Eur Respir J. 1991; 4:1161-5. Editorial.

114. Kamada AK, Spahn JD, Blake KV. Salmeterol: its place in asthma management. Ann Pharmacother. 1994; 28:1100-2. [IDIS 335815] [PubMed 7803888]

115. Wanner A. Is the routine use of inhaled β-adrenergic agonists appropriate in asthma treatment? Yes. Am J Respir Crit Care Med. 1995; 151:597-9. [IDIS 344522] [PubMed 7881643]

116. Sears MR. Is the routine use of inhaled β-adrenergic agonists appropriate in asthma treatment? No. Am J Respir Crit Care Med. 1995; 151:600-1. [IDIS 344523] [PubMed 7881644]

117. Lai CKW, Twentyman OP, Holgate ST. The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the asssociated change in nonspecific bronchial responsiveness. Am Rev Respir Dis. 1989; 140:917-23. [IDIS 310468] [PubMed 2572192]

118. Suissa S, Ernst P, Boivin JF et al. A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists. Am J Respir Crit Care Med. 1994; 149(3 Part 1):604-10. [IDIS 327105] [PubMed 8118625]

119. O’Connor BJ, Aikman SL, Barnes PJ. Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. N Engl J Med. 1992; 327:1204-8. [IDIS 304091] [PubMed 1357551]

120. Cockcroft DW, McParland CP, Britto SA et al. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet. 1993; 342:833-7. [IDIS 320479] [PubMed 8104272]

121. Mullen ML, Mullen B, Carey M. The association between β-agonist use and death from asthma: a meta-analytic integration of case-control studies. JAMA. 1993; 270:1842-5. [IDIS 320909] [PubMed 8105113]

122. Reviewers’ comments (personal observations) on Salmeterol 12:12.

123. National Institutes of Health, National Heart, Lung, and Blood Institute. Global Initiative for asthma: global strategy for asthma management and prevention NHLBI/WHO Workshop Report. Bethesda, MD: National Institutes of Health. 1995 Jan:77-100. NIH/NHLBI Publication No. 95-3659.

124. Devoy MAB, Fuller RW, Palmer JBD. Are there any detrimental effects of the use of inhaled long-acting β2-agonists in the treatment of asthma? Chest. 1995; 107:1116-24.

125. McFadden ER Jr. Perspectives in β2-agonist therapy: vox clamantis in deserto vel lux in tenebris? J Allergy Clin Immunol. 1995; 95:641-51.

126. Crane J, Burgess C, Pearce N et al. Asthma deaths in New Zealand. BMJ. 1992; 304:1307. [IDIS 296806] [PubMed 1606438]

127. Crane J, Pearce N, Flatt A et al. Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study. Lancet. 1989; 1:917-22. [IDIS 254874] [PubMed 2565417]

128. Pearlman DS, Chervinsky P, LaForce C et al. A comparison of salmeterol with albuterol in the treatment of mild-to-moderate asthma. N Engl J Med. 1992; 327:1420-5.

129. D’Alonzo GE, Nathan RA, Henochowicz S et al. Salmeterol xinafoate as maintenance therapy compared with albuterol in patients with asthma. JAMA. 1994; 271:1412-6.

130. National Asthma Education and Prevention Program. Expert panel report II: guidelines for the diagnosis and management of asthma. 1997 Feb.

131. Drazen JM, Israel E, Boushey HA et al. Comparison of regularly scheduled with as- needed use of albuterol in mild asthma. N Engl J Med. 1996; 335:841-7.

132. Abbott Laboratories. Isoproterenol hydrochloride injection, USP 1:5000 and 1:50,000 prescribing information. North Chicago, IL; 1998 Oct.

133. The American Heart Association in Collaboration with the International Liaison Committee on Resuscitation. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2000; 102(Suppl I)I-123.

134. Food and Drug Administration. Isuprel (isoproterenol HCl) injection [February 23, 2000: Abbott]. MedWatch drug labeling changes. Rockville, MD; February 2000. From FDA website.

135. Abbott Laboratories. Isuprel (Isoproterenol hydrochloride injection, USP 1:5000) prescribing information. North Chicago, IL; 1999 Feb.

136. The American Heart Association. Guidelines 2005 for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005; 112(Suppl I): IV1-211.

137. Eigel B. (American Heart Association, Dallas, TX): Personal communication; 2006 Aug 16.

140. Valeant. Isoproterenol hydrochloride injection prescribing information. Bridgewater, NJ; 2015 Feb.

153. Dellinger RP, Levy MM, Rhodes A et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013; 39:165-228. [PubMed 23361625]

170. World Health Organization. SDB WHO Single Medicines Review: Isoprenaline. From WHO website.

401. Neumar RW, Otto CW, Link MS et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010; 122(18 Suppl 3):S729-67. [PubMed 20956224]

HID. McEvoy GK, ed. Handbook on injectable drugs. 18th ed. Bethesda, MD: American Society of Health-System Pharmacists, Inc; 2015:449-50..

a. AHFS Drug Information 2017. McEvoy GK, ed. Isoproterenol. American Society of Health System Pharmacists; 2017.