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Innohep Dosage

Medically reviewed by Last updated on Sep 27, 2021.

Generic name: TINZAPARIN SODIUM 20000[iU] in 1mL
Dosage form: injection, solution

All patients should be evaluated for bleeding disorders before administration of INNOHEP®. Since coagulation parameters are unsuitable for monitoring INNOHEP® activity, routine monitoring of coagulation parameters is not required (see PRECAUTIONS, Laboratory Tests).

Adult Dosage

The recommended dose of INNOHEP® for the treatment of DVT with or without PE is 175 anti-Xa IU/kg of body weight, administered SC once daily for at least 6 days and until the patient is adequately anticoagulated with warfarin (INR at least 2.0 for two consecutive days). Warfarin sodium therapy should be initiated when appropriate (usually within 1-3 days of INNOHEP® initiation). Pregnancy has little or no influence on the pharmacokinetics of INNOHEP® and no dosing adjustment is needed for pregnancy.

As INNOHEP® may theoretically affect the PT/INR, patients receiving both INNOHEP® and warfarin should have blood for PT/INR determination drawn just prior to the next scheduled dose of INNOHEP®.

Table 8 provides INNOHEP® doses for the treatment of DVT with or without PE. It is necessary to calculate the appropriate INNOHEP® dose for patient weights not displayed in Table 8.

An appropriately calibrated syringe should be used to assure withdrawal of the correct volume of drug from INNOHEP® vials.

Table 8 INNOHEP® Weight-based Dosing for Treatment of Deep Vein Thrombosis With or Without Symptomatic Pulmonary Embolism
DVT Treatment
Patient Body
Weight in

175 IU/kg SC Once Daily
20,000 IU per mL
Patient Body
Weight in

68-80 6,000 0.3 31-36
81-94 7,000 0.35 37-42
95-107 8,000 0.4 43-48
108-118 9,000 0.45 49-53
119-131 10,000 0.5 54-59
132-144 11,000 0.55 60-65
145-155 12,000 0.6 66-70
156-168 13,000 0.65 71-76
169-182 14,000 0.7 77-82
183-195 15,000 0.75 83-88
196-206 16,000 0.8 89-93
207-219 17,000 0.85 94-99
220-232 18,000 0.9 100-105
233-243 19,000 0.95 106-110
244-256 20,000 1 111-116
257-270 21,000 1.05 117-122
271-283 22,000 1.1 123-128
284-294 23,000 1.15 129-133
295-307 24,000 1.2 134-139
308-320 25,000 1.25 140-145
321-331 26,000 1.3 146-150
332-344 27,000 1.35 151-156
345-358 28,000 1.4 157-162

To calculate the volume (mL) of an INNOHEP® 175 anti-Xa IU per kg SC dose for treatment of deep vein thrombosis:

Patient weight (kg) X 0.00875 mL/kg = volume to be administered (mL) subcutaneously


INNOHEP® is a clear, colorless to slightly yellow solution, and as with other parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

INNOHEP® is administered by SC injection. It must not be administered by intramuscular or intravenous injection.

Subcutaneous Injection Technique: Patients should be lying down (supine) or sitting and INNOHEP® administered by deep SC injection. Administration should be alternated between the left and right anterolateral and left and right posterolateral abdominal wall. The injection site should be varied daily. The whole length of the needle should be introduced into a skin fold held between the thumb and forefinger; the skin fold should be held throughout the injection. To minimize bruising, do not rub the injection site after completion of the injection.

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