Influenza Virus Vaccine, Inactivated Dosage
Medically reviewed by Drugs.com. Last updated on Aug 13, 2024.
Applies to the following strengths: trivalent; preservative-free quadrivalent; preservative-free trivalent; quadrivalent; preservative-free pediatric quadrivalent; recombinant hemagglutinin trivalent preservative-free; recombinant hemagglutinin quadrivalent; high-dose preservative-free quadrivalent; high-dose preservative-free trivalent; preservative-free mdck cell derived trivalent; adjuvanted preservative-free trivalent; adjuvanted preservative-free quadrivalent; preservative-free mdck cell derived quadrivalent; mdck cell derived quadrivalent; mdck cell derived trivalent
Usual Adult Dose for:
Usual Geriatric Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Influenza Prophylaxis
0.5 mL IM once
Comment:
- Some vaccine formulations are only approved for older adults.
Use: For active immunization against influenza disease caused by influenza virus subtypes A and types B contained in the vaccine
Usual Geriatric Dose for Influenza Prophylaxis
65 years and older:
- Fluad: 0.5 mL IM once
- Fluzone High-Dose Trivalent: 0.5 mL IM once
- Fluzone High-Dose Quadrivalent: 0.7 mL IM once
Comments:
- Consult the manufacturer product information prior to administration to confirm dosing volume and approved age range for the vaccine formulation used.
- Dosing in trivalent and quadrivalent versions of the Fluad vaccine does not differ.
Use: For active immunization against influenza disease caused by influenza virus subtypes A and types B contained in the vaccine
Usual Pediatric Dose for Influenza Prophylaxis
FLUCELVAX:
- Patients 6 months to less than 9 years: 0.5 mL IM for 1 or 2 doses
- Patients 9 years or older: 0.5 mL IM once
FLULAVAL AND FLUARIX:
- Patients 6 months to less than 9 years:
- NOT previously vaccinated/history unknown: 0.5 mL IM for 2 doses
- Previously vaccinated: 0.5 mL IM for 1 or 2 doses
- Patients 9 years and older: 0.5 mL IM once
AFLURIA:
- Patients 6 months to less than 3 years: 0.25 mL IM for 1 or 2 doses
- Patients 3 years to less than 9 years: 0.5 mL IM for 1 or 2 doses
- Patients 9 years and older: 0.5 mL IM once
FLUZONE:
- Patients 6 months to less than 3 years:
- NOT previously vaccinated/history unknown: 0.25 mL OR 0.5 mL IM for 2 doses
- Previously vaccinated: 0.25 mL OR 0.5 mL IM for 1 or 2 doses
- If administering 2 doses, a combination of any dosing volumes can be used.
- Patients 3 years to less than 9 years:
- NOT previously vaccinated/history unknown: 0.5 mL IM for 2 doses
- Previously vaccinated: 0.5 mL IM for 1 or 2 doses
- Patients 9 years and older: 0.5 mL IM once
Comments:
- If administering 2 doses of vaccine, separate each dose by at least 1 month (4 weeks) apart.
- To determine whether a child requires 1 or 2 doses based on vaccine history, consult the Advisory Committee on Immunization Practices (ACIP) annual recommendations on the prevention and control of influenza.
- Some manufacturers recommend that children under 9 years of age who have NOT been previously vaccinated with an influenza vaccine should receive 2 doses.
- The approved age for vaccine administration, dose volume/schedule, and injection delivery system may vary across products; consult the manufacturer product information prior to vaccination.
- Dosing in trivalent and quadrivalent versions of Afluria, Flucelvax, Fluarix, Flulaval, and Fluzone vaccines do not differ.
Use: For active immunization against influenza disease caused by influenza virus subtypes A and types B contained in the vaccine
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Administration of this vaccine to anyone with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine, including egg protein, or to a previous dose of any influenza vaccine
Safety and efficacy have not been established in patients younger than 6 months.
- Flublok and Pharmajet Stratis Needle-Free Injection System: Safety and efficacy have not been established in patients younger than 18 years.
- Fluad, Fluzone High-Dose, and Pharmajet Stratis Needle-Free Injection System: Safety and efficacy have not been established in patients younger than 65 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- For intramuscular injection only.
- The preferred site for intramuscular injection is the deltoid muscle of the upper arm.
- Children with insufficient deltoid mass should be vaccinated in the anterolateral aspect of the thigh.
- If this vaccine is given at the same time as another injectable vaccine, separate injection sites.
- Do not inject this vaccine in the gluteal region or areas where there may be a major nerve trunk.
- Do not administer this product intravenously, intradermally, or subcutaneously.
Storage requirements:
- Store refrigerated between 2C and 8C (36F and 46F).
- Do not freeze; discard if product has been frozen.
- Protect from light.
- Multi-dose vials:
- Between uses, return to recommended storage conditions between 2C and 8C (36 and 46F).
- Discard after 28 days once stopper has been first pierced.
- Needle puncture limits: Consult the manufacturer product information.
Reconstitution/preparation techniques:
- Do not combine through reconstitution or mix with any other vaccine.
- Inspect for particulate matter and/or discoloration; do not administer if either condition exists.
- Shake prefilled syringe or vial well prior to administration.
- Prefilled syringes are for single-use only.
General:
- Vaccine Information Statements (VIS) must be provided to vaccine recipients or their guardians; refer to the US CDC website for materials (www.cdc.gov/vaccines).
Patient advice:
- Read the US FDA-approved patient labeling (Patient Information and VIS).
- Understand that this vaccine contains killed virus and cannot cause influenza
- Recognize that this vaccine only protects against influenza and not other respiratory illnesses.
- Report any adverse events to your health care provider and/or to the Vaccine Adverse Event Reporting System (VAERS).
- Patients vaccinated while pregnant: A pregnancy registry is available for some formulations.
Frequently asked questions
- How and where is a flu shot injection given?
- What flu vaccine can I use with an egg allergy?
- How well does the flu vaccine work?
- Where can I get the flu vaccine right now?
- How can I get a flu vaccine without a needle?
- Which flu vaccines are available?
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- During pregnancy
- Drug class: viral vaccines
Patient resources
- Influenza virus vaccine injection drug information
- Influenza virus vaccine (Advanced Reading)
- Influenza virus vaccine recombinant (Advanced Reading)
- Influenza virus vaccine, adjuvanted (Advanced Reading)
- Influenza Virus Vaccine (Inactivated)
Other brands
Fluzone, Afluria, Fluad, Flucelvax Quadrivalent, ... +18 more
Professional resources
- Influenza Vaccine Inactivated monograph
- Influenza Vaccine Recombinant (AHFS Monograph)
- Fluzone Southern Hemisphere (FDA)
Other brands
Afluria, Fluad, Fluarix, Flucelvax, ... +11 more
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Further information
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