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Gleostine Dosage

Generic name: LOMUSTINE 40mg
Dosage form: capsule, gelatin coated

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Important Prescribing and Dispensing Information

PRESCRIBE ONLY ONE DOSE FOR EACH TREATMENT CYCLE. DO NOT DISPENSE ENTIRE CONTAINER. Dispense only a sufficient number of capsules for one dose.

Confirm the total dose prescribed by the physician and the appropriate combination of capsule strengths.

Dispense only the appropriate number of Gleostine capsules required for the administration of a single dose.

The prescribed dose may consist of two or more different strengths and colors of capsules.

Instruct patients that Gleostine is taken as a single oral dose and will not be repeated for at least 6 weeks. Taking more than the recommended dose causes toxicities, including fatal outcomes [see Warnings and Precautions ( 5.2) and Overdosage ( 10)] .

Gleostine is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1

To minimize the risk of dermal exposure, always wear impervious gloves when handling bottles containing Gleostine capsules. Do not break Gleostine capsules; avoid exposure to broken capsules. If dermal contact occurs, wash areas of skin contact immediately and thoroughly.

Recommended Dose

The recommended dose of Gleostine in adult and pediatric patients is 130 mg/m 2 taken as a single oral dose every 6 weeks. Round doses to the nearest 5 mg. Give as a single oral dose and do not repeat for at least 6 weeks. Reduce dose to 100 mg/m 2 every 6 weeks in patients with compromised bone marrow function. Also reduce dose accordingly when using with other myelosuppressive drugs.

Dose Modifications

Perform weekly complete blood counts and withhold each subsequent dose for more than 6 weeks if needed until platelet counts recover to 100,000/mm 3 or greater and leukocytes recover to 4000/mm 3or greater [see Warnings and Precautions ( 5.1)] .

Modify each dose of Gleostine according to the hematologic response of the preceding dose as described in Table 1:

Table 1. Dose Modifications for Gleostine
Nadir After r Prior Dose Dose Adjustment
Leukocytes (/mm3) Platelets (/mm3)
≥ 4000 ≥ 100,000 None
3000 – 3999 75,000 – 99,999 None
2000 – 2999 25,000 – 74,999 Reduce dose by 30%
< 2000 < 25,000 Reduce dose by 50%