Generic name: GADOXETATE DISODIUM 181.43mg in 1mL
Dosage form: injection, solution
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The recommended dose of EOVIST is 0.1 mL/kg body weight (0.025 mmol/kg body weight).
Drug Handling and Administration
- Use sterile technique when preparing and administering EOVIST
- Visually inspect EOVIST, supplied in a single-use vial, for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored or if particulate matter is present
- Use EOVIST immediately after obtaining appropriate dose from vial. The rubber stopper should never be pierced more than once. Discard any unused portion of an EOVIST vial
- Administer EOVIST undiluted as an intravenous bolus injection at a flow rate of approximately 2 mL/second
- Do not mix EOVIST with other medications and do not administer EOVIST in the same intravenous line simultaneously with other medications
- Flush the intravenous cannula with a normal saline solution after EOVIST injection
- Imaging can commence immediately following EOVIST administration
- Liver lesions are detected and characterized with pre-contrast MRI and EOVIST MRI obtained during dynamic and hepatocyte imaging phases. Perform a pre-contrast MRI, inject EOVIST and begin dynamic imaging approximately 15–25 seconds after completion of the injection. Dynamic imaging consists of the arterial, the porto-venous (approximately 60 seconds post-injection), and the blood equilibrium (approximately 120 seconds) phases.
- Begin the hepatocyte imaging phase approximately 20 minutes post-injection. Hepatocyte phase imaging may be performed up to 120 minutes post-injection.
- Elevated intrinsic levels of bilirubin (>3 mg/dL) or ferritin can reduce the hepatic contrast effect of EOVIST. Perform MR imaging no later than 60 minutes following EOVIST administration to patients with these laboratory abnormalities, including patients who have elevated ferritin levels due to hemodialysis [see Warnings and Precautions (5.6) and Use in Specific Populations (8.6, 8.7)].
- Lesions with no or minimal hepatocyte function (cysts, metastases, and the majority of hepatocellular carcinomas) generally will not accumulate EOVIST. Well-differentiated hepatocellular carcinoma may contain functioning hepatocytes and can show some enhancement in the hepatocyte imaging phase. Additional clinical information is therefore needed to support a diagnosis of hepatocellular carcinoma.
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- Drug class: magnetic resonance imaging contrast media