Eovist Dosage
Generic name: GADOXETATE DISODIUM 181.43mg in 1mL
Dosage form: injection, solution
Drug class: Magnetic resonance imaging contrast media
Drug Handling and Administration
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- Use sterile technique when preparing and administering EOVIST
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- Visually inspect EOVIST, supplied in a single-dose container (vial), for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored or if particulate matter is present
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- Use EOVIST immediately after obtaining appropriate dose from vial. The rubber stopper should never be pierced more than once. Discard any unused portion of an EOVIST vial
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- Administer EOVIST undiluted as an intravenous injection at a recommended rate of 1 mL to 2 mL per second.
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- Do not mix EOVIST with other medications and do not administer EOVIST in the same intravenous line simultaneously with other medications
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- Flush the intravenous cannula with a normal saline solution after EOVIST injection
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- Imaging can commence immediately following EOVIST administration
Imaging
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- Liver lesions are detected and characterized with pre-contrast MRI and EOVIST MRI obtained during dynamic and hepatocyte imaging phases. Perform a pre-contrast MRI, inject EOVIST and begin dynamic imaging approximately 15–25 seconds after completion of the injection. Dynamic imaging consists of the arterial, the porto-venous (approximately 60 seconds post-injection), and the blood equilibrium (approximately 120 seconds) phases.
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- Begin the hepatocyte imaging phase approximately 20 minutes post-injection. Hepatocyte phase imaging may be performed up to 120 minutes post-injection.
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- Elevated intrinsic levels of bilirubin (>3 mg/dL) or ferritin can reduce the hepatic contrast effect of EOVIST. Perform MR imaging no later than 60 minutes following EOVIST administration to patients with these laboratory abnormalities, including patients who have elevated ferritin levels due to hemodialysis.
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- Lesions with no or minimal hepatocyte function (cysts, metastases, and the majority of hepatocellular carcinomas) generally will not accumulate EOVIST. Well-differentiated hepatocellular carcinoma may contain functioning hepatocytes and can show some enhancement in the hepatocyte imaging phase. Additional clinical information is therefore needed to support a diagnosis of hepatocellular carcinoma.
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Further information
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