Dehydroepiandrosterone Dosage

Medically reviewed by Drugs.com. Last updated on Jul 10, 2023.

Usual Adult Dose for Postmenopausal Symptoms

Prasterone 6.5 mg vaginal insert: Administer 1 insert intravaginally once a day at bedtime

Comments:

• Administer this drug using the provided applicator.

Use: For the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS (PRASTERONE VAGINAL INSERT):

• Undiagnosed abnormal genital bleeding: Any postmenopausal woman with undiagnosed, persistent or recurring genital bleeding should be evaluated to determine the cause of the bleeding before consideration of treatment with this drug.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Prasterone insert is for vaginal use only.
• Each applicator is for one-time intravaginal use with 1 vaginal insert.
• To activate the applicator, pull back on the plunger before use and insert the unwrapped, flat end of the vaginal insert into the open end of applicator.
• If the vaginal insert falls on an unsanitary surface, replace it with a new one.
• Place the insert into the vagina using the activated applicator as far as it can comfortably go without force.
• Press the plunger to release the insert within the vagina and then withdraw the applicator.
• Discard applicator after use.

Storage requirements:

• Store prasterone at 41F to 86F (5C to 30C).
• May be stored at room temperature or in the refrigerator.

Patient advice:

• Read the FDA-approved patient labeling for prasterone (Patient Information and Instructions for Use).
• Inform postmenopausal women that abnormal Pap smear findings may occur with use of prasterone.
• Advise women that increased vaginal discharge may occur with the use of prasterone.
• Inform patients to alert their healthcare provider(s) of any history of breast cancer or undiagnosed vaginal bleeding prior to use of this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer