Corticorelin Dosage
Applies to the following strengths: 100 mcg
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cushing's Syndrome
Testing dose: 1 mcg/kg IV over 30 seconds
-Doses greater than 1 mcg/kg are not recommended
Comments:
-Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.
Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Usual Pediatric Dose for Cushing's Syndrome
Testing dose: 1 mcg/kg IV over 30 seconds
-Doses greater than 1 mcg/kg are not recommended
Comments:
-Limited data in pediatric patients.
-Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.
Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
-Hypersensitivity to ovine corticorelin or any product excipients
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-For intravenous injection only
-Some of the adverse effects can be reduced by administering as an infusion over 30 seconds instead of as a bolus injection
Reconstitution/preparation techniques:
-Reconstitute vial with 2 mL of solidum chloride injection; to avoid bubble formation, do not shake
-Roll the vial to dissolve product
Storage:
-Store refrigerated 2C to 8C (36F to 46F); protect from light
-Reconstituted solution: Stable for up to 8 hours when refrigerated
General:
-If a repeated evaluation is needed, the repeat test should be carried out at the same time of day as the original test.
-ACTH and cortisol responses are prolonged and remain elevated for up to 2 hours; maximum increment in plasma ACTH occurs between 15 and 60 minutes following administration with the maximum increment in plasma cortisol occurring between 30 and 120 minutes
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.