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Corticorelin Dosage

Applies to the following strengths: 100 mcg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cushing's Syndrome

Testing dose: 1 mcg/kg IV over 30 seconds
-Doses greater than 1 mcg/kg are not recommended

Comments:
-Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.

Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Usual Pediatric Dose for Cushing's Syndrome

Testing dose: 1 mcg/kg IV over 30 seconds
-Doses greater than 1 mcg/kg are not recommended

Comments:
-Limited data in pediatric patients.
-Some adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.

Use: Differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to ovine corticorelin or any product excipients

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-For intravenous injection only
-Some of the adverse effects can be reduced by administering as an infusion over 30 seconds instead of as a bolus injection

Reconstitution/preparation techniques:
-Reconstitute vial with 2 mL of solidum chloride injection; to avoid bubble formation, do not shake
-Roll the vial to dissolve product

Storage:
-Store refrigerated 2C to 8C (36F to 46F); protect from light
-Reconstituted solution: Stable for up to 8 hours when refrigerated

General:
-If a repeated evaluation is needed, the repeat test should be carried out at the same time of day as the original test.
-ACTH and cortisol responses are prolonged and remain elevated for up to 2 hours; maximum increment in plasma ACTH occurs between 15 and 60 minutes following administration with the maximum increment in plasma cortisol occurring between 30 and 120 minutes

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.