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Cobicistat / Darunavir Dosage

Medically reviewed by Drugs.com. Last updated on May 2, 2022.

Applies to the following strengths: 150 mg-800 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for HIV Infection

1 tablet orally once a day with food

Comments:


Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in therapy-naive and therapy-experienced patients without darunavir resistance-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V)

Usual Pediatric Dose for HIV Infection

At least 40 kg: 1 tablet orally once a day with food

Comments:


Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in therapy-naive and therapy-experienced patients without darunavir resistance-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V)

Renal Dose Adjustments

No adjustment recommended.

Estimated CrCl less than 70 mL/min: Coadministration with tenofovir disoproxil fumarate (DF) is not recommended.

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Not recommended.

Precautions

CONTRAINDICATIONS:
Coadministration with alfuzosin, ranolazine, dronedarone, ivabradine, carbamazepine, phenobarbital, phenytoin, colchicine (in patients with renal and/or liver dysfunction), rifampin, lurasidone, pimozide, ergot derivatives (e.g., dihydroergotamine, ergotamine, methylergonovine), cisapride, St. John's wort, elbasvir-grazoprevir, lomitapide, lovastatin, simvastatin, naloxegol, oral midazolam, triazolam, sildenafil (for treatment of pulmonary arterial hypertension)

Safety and efficacy have not been established in pediatric patients weighing less than 40 kg.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Comments:

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.